ArticleChemosphere2023
Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa.
Article in Chemosphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Development and validation of matrix-validated LC-MS/MS method for simultaneous quantification of 21 neonicotinoids and their metabolites in human urine.Environmental science and pollution research international · 2026Article
- Article
- Neonicotinoid-Induced Cytotoxicity: Insights into Cellular Mechanisms and Health Risks.Toxics · 2025Review
- Environmental contamination associated with biofuel production involving pesticide-coated seed corn as feedstock: a survey of community environmental and health impacts.Environmental health : a global access science source · 2025Article
- Small volume solid phase extraction method for comprehensive analysis of neonicotinoids, their metabolites, and related pesticides in water.The Science of the total environment · 2024Article
- Human acute poisoning incidents associated with neonicotinoid pesticides in the U.S. Incident Data System (IDS) database from 2018-2022 - frequency and severity show public health risks, regulatory failures.Environmental health : a global access science source · 2024Article
- Associations between neonicotinoids and liver function measures in US adults: National Health and Nutrition Examination Survey 2015-2016.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Nitrate exposure from drinking water and dietary sources among Iowa farmers using private wells.The Science of the total environment · 2024Article
- Review
- Paralysis caused by dinotefuran at environmental concentration via interfering the CaFrontiers in public health · 2024Article
- Long-term exposure to environmental concentration of dinotefuran disrupts ecdysis and sex ratio by dysregulating related gene expressions inFrontiers in endocrinology · 2024Article
- Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies.Analytical and bioanalytical chemistry · 2023Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
A pilot study among farming households in eastern Iowa was conducted to assess human exposure to neonicotinoids (NEOs). The study was in a region with intense crop and livestock production and where groundwater is vulnerable to surface-applied contaminants. In addition to paired outdoor (hydrant) water and indoor (tap) water samples from private wells, urine samples were collected from 47 adult male pesticide applicators along with the completions of dietary and occupational surveys. Estimated Daily Intake (EDI) were then calculated to examine exposures for different aged family members. NEOs were detected in 53% of outdoor and 55% of indoor samples, with two or more NEOs in 13% of samples. Clothianidin was the most frequently detected NEO in water samples. Human exposure was ubiquitous in urine samples. A median of 10 different NEOs and/or metabolites were detected in urine, with clothianidin, nitenpyram, thiamethoxam, 6-chloronicotinic acid, and thiacloprid amide detected in every urine samples analyzed. Dinotefuran, imidaclothiz, acetamiprid-N-desmethyl, and N-desmethyl thiamethoxam were found in ≥70% of urine samples. Observed water intake for study participants and EDIs were below the chronic reference doses (CRfD) and acceptable daily intake (ADI) standards for all NEOs indicating minimal risk from ingestion of tap water. The study results indicate that while the consumption of private well tap water provides a human exposure pathway, the companion urine results provide evidence that diet and/or other exposure pathways (e.g., occupational, house dust) may contribute to exposure more than water contamination. Further biomonitoring research is needed to better understand the scale of human exposure from different sources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.