Evidence map›Paper›PMID 36709553›Full record

ArticleJournal of geriatric oncology2023

The 10-month mortality rate among older patients treated for digestive system cancer during the first wave of the COVID-19 pandemic: The CADIGCOVAGE multicentre cohort study.

Thomas Aparicio, Richard Layese, François Hemery, Christophe Tournigand, Elena Paillaud, Nicola De Angelis, Laurent Quero, Nathalie Ganne, Fredéric Prat, Atanas Pachev and 4 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of geriatric oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Thomas AparicioAP-HP, Saint Louis Hospital, Gastroenterology and Digestive Oncology Department, F-75010 Paris, France; Université de Paris, F-75000 Paris, France. Electronic address: thomas.aparicio@aphp.fr.
Richard LayeseAP-HP, Henri-Mondor Hospital, Public Health and Clinical Research department (URC Mondor), F-94010 Créteil, France; Univ Paris Est Creteil, INSERM, IMRB U955, F-94000 Creteil, France.
François HemeryAP-HP, Henri-Mondor Hospital, Medical Information Departement, F-94010 Créteil, France.
Christophe TournigandAP-HP, Henri-Mondor Hospital, Medical Oncology Department, F-94010 Créteil, France.
Elena PaillaudUniv Paris Est Creteil, INSERM, IMRB U955, F-94000 Creteil, France; AP-HP, Paris Cancer Institute CARPEM, Georges Pompidou Hospital, Geriatric Department, F-75015 Paris, France.
Nicola De AngelisAP-HP, Henri-Mondor Hospital, Digestive Surgery, F-94010 Créteil, France.
Laurent QueroUniversité de Paris, F-75000 Paris, France; AP-HP, Saint Louis Hospital, Radiotherapy Department, F-75010 Paris, France.
Nathalie GanneAP-HP, Avicenne Hospital, Hepatology Department, F-93000 Bobigny, France.
Fredéric PratUniversité de Paris, F-75000 Paris, France; AP-HP, Beaujon Hospital, Endoscopy Department, F-92110 Clichy, France.
Atanas PachevAP-HP, Saint Louis Hospital, Radiology Department, F-75010 Paris, France.
Gilles GalulaAP-HP, Tenon Hospital, Medical Oncology, F-75020 Paris, France.
Marc-Antoine BenderraAP-HP, Tenon Hospital, Medical Oncology, F-75020 Paris, France.
Florence Canouï-PoitrineAP-HP, Henri-Mondor Hospital, Public Health and Clinical Research department (URC Mondor), F-94010 Créteil, France; Univ Paris Est Creteil, INSERM, IMRB U955, F-94000 Creteil, France.
Clinical Data Warehouse of Greater Paris University Hospitals/INSERM COVID-19 research collaboration and the Cancer AP-HP Group
Assistance Publique – Hôpitaux de Paris · FRHôpital Saint-Louis · FRCentre Hospitalier Universitaire Henri-Mondor · FRHôpital Tenon · FRHôpitaux Universitaires Henri-Mondor · FRInstitut Mondor de Recherche Biomédicale · FRUniversité Paris-Est Créteil · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe coronavirus disease 2019 (COVID-19) pandemic has had a dramatic impact on cancer diagnosis and care pathways. Here, we assessed the mid-term impact of the COVID-19 pandemic on older adults with cancer before, during and after the lockdown period in 2020. MATERIALS AND

methodsWe performed a retrospective, observational, multicentre cohort study of prospectively collected electronic health records. All adults aged 65 or over and having been newly treated for a digestive system cancer in our institution between January 2018 until August 2020 were enrolled.

resultsData on 7,881 patients were analyzed. Although the overall 10-month mortality rate was similar in 2020 vs. 2018-2019, the mortality rate among for patients newly treated in the 2020 post-lockdown period was (after four months of follow-up) significantly higher. A subgroup analysis revealed higher mortality rates for (i) patients diagnosed in the emergency department during the pre-lockdown period, (ii) patients with small intestine cancer newly treated during the post-lockdown period, and (iii) patients having undergone surgery with curative intent during the post-lockdown period. However, when considering individuals newly treated during the lockdown period, we observed lower mortality rates for (i) patients aged 80 and over, (ii) patients with a biliary or pancreatic cancer, and (iii) patients diagnosed in the emergency department. DISCUSSION: There was no overall increase in mortality among patients newly treated in 2020 vs. 2018-2019. Longer follow-up is needed to assess the consequences of the pandemic. A subgroup analysis revealed significant intergroup differences in mortality.

Indexed as

COVID-19Digestive System NeoplasmsAgedAged, 80 and overCohort StudiesCommunicable Disease ControlHumansPandemicsRetrospective StudiesSARS-CoV-2Biliary tract cancerColorectal cancerCOVID-19Gastric cancerHepatocellular carcinomaLockdownOesophageal cancerOlder patientsPancreatic cancer

Identifiers

PMID36709553
PMCPMC9883010
OpenAlexW4318203704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.