Evidence map›Paper›PMID 36709433›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2022

Main and moderated effects of multimorbidity and depressive symptoms on cognition.

Jacyra Azevedo Paiva de Araujo, Érika Fialho Morais Xavier, Elisângela da Silva Rodrigues, Daiane Borges Machado, Marcos E Barreto, Richard A Kanaan, Mauricio L Barreto, Luis Fernando Silva Castro-de-Araujo

Open access · diamondAbstract read
In one paragraph

Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jacyra Azevedo Paiva de AraujoCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil.
Érika Fialho Morais XavierCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil.
Elisângela da Silva RodriguesCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil. Universidade Federal do Ceará, Itapajé, CE, Brazil.
Daiane Borges MachadoCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil. Department Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
Marcos E BarretoCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil. Department of Statistics, London School of Economics and Political Science, London, UK.
Richard A KanaanDepartment of Psychiatry, University of Melbourne, Austin Health, Melbourne, Victoria, Australia.
Mauricio L BarretoCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil.
Luis Fernando Silva Castro-de-AraujoCentro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil. Department of Psychiatry, University of Melbourne, Austin Health, Melbourne, Victoria, Australia.
Fundação Oswaldo Cruz · BRKnowledge Integration (United Kingdom) · GBAustin Health · AU

Funding

The impact of social drivers, conditional cash transfers and their mechanisms on mental health of the young: an integrated retrospective and forecasting approach using the 100 million Brazilian CohortR01MH128911 · NIMH · FUNDACAO OSWALDO CRUZ · PI Daiane Borges Machado · 2022 to 2026
$1.9M
Biotechnology and Biological Sciences Research Council BB/H008217/1NIMH NIH HHS R01 MH128911
6 · The paper itself

Abstract

objectiveMultimorbidity, or the occurrence of two or more chronic conditions, is a global challenge, with implications for mortality, morbidity, disability, and life quality. Psychiatric disorders are common among the chronic diseases that affect patients with multimorbidity. It is still not well understood whether psychiatric symptoms, especially depressive symptoms, moderate the effect of multimorbidity on cognition.

methodsWe used a large (n=2,681) dataset to assess whether depressive symptomatology moderates the effect of multimorbidity on cognition using structural equation modelling.

resultsIt was found that the more depressive symptoms and chronic conditions, the worse the cognitive performance, and the higher the educational level, the better the cognitive performance. We found a significant but weak (0.009; p = 0.04) moderating effect.

conclusionWe have provided the first estimate of the moderating effect of depression on the relation between multimorbidity and cognition, which was small. Although this moderation has been implied by many previous studies, it was never previously estimated.

Indexed as

DepressionMultimorbidityChronic DiseaseCognitionHumansQuality of LifeagingepidemiologyMultimorbiditystructural equation modeling

Identifiers

PMID36709433
PMCPMC9851765
OpenAlexW4284988938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.