Evidence map›Paper›PMID 36709345›Full record

ArticleNature communications2023

Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands.

Y Wang, E R Zoneff, J W Thomas, N Hong, L L Tan, D J McGillivray, A W Perriman, K C L Law, L H Thompson, N Moriarty and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Y WangLaboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University, Canberra, ACT, 2601, Australia.ORCID 0000-0001-6082-8721
E R ZoneffLaboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University, Canberra, ACT, 2601, Australia.
J W ThomasLaboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University, Canberra, ACT, 2601, Australia.
N HongResearch School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.ORCID 0000-0002-7997-7687
L L TanResearch School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.ORCID 0000-0003-0606-4446
D J McGillivraySchool of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.ORCID 0000-0003-2127-8792
A W PerrimanResearch School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.
K C L LawThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.ORCID 0000-0001-6652-0445
L H ThompsonThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
N MoriartyThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
C L ParishThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.ORCID 0000-0001-8212-9884
R J WilliamsInstitute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Warun Ponds, VIC, 3216, Australia.ORCID 0000-0003-3831-8738
C J JacksonResearch School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia. colin.jackson@anu.edu.au.ORCID 0000-0001-6150-3822
D R NisbetLaboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, Australian National University, Canberra, ACT, 2601, Australia. david.nisbet@unimelb.edu.au.
Australian National University · AUThe University of Melbourne · AUDeakin University · AUUniversity of Auckland · NZ

Funding

Medical Research Council MR/S016430/1
6 · The paper itself

Abstract

Injectable biomimetic hydrogels have great potential for use in regenerative medicine as cellular delivery vectors. However, they can suffer from issues relating to hypoxia, including poor cell survival, differentiation, and functional integration owing to the lack of an established vascular network. Here we engineer a hybrid myoglobin:peptide hydrogel that can concomitantly deliver stem cells and oxygen to the brain to support engraftment until vascularisation can occur naturally. We show that this hybrid hydrogel can modulate cell fate specification within progenitor cell grafts, resulting in a significant increase in neuronal differentiation. We find that the addition of myoglobin to the hydrogel results in more extensive innervation within the host tissue from the grafted cells, which is essential for neuronal replacement strategies to ensure functional synaptic connectivity. This approach could result in greater functional integration of stem cell-derived grafts for the treatment of neural injuries and diseases affecting the central and peripheral nervous systems.

Indexed as

HydrogelsNeural Stem CellsCell DifferentiationMyoglobinNeuronsOxygenHydrogelsMyoglobinOxygen

Identifiers

PMID36709345
PMCPMC9884236
OpenAlexW4318323831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.