ArticleBMC endocrine disorders2023
The effect of different types of anemia on HbA1c levels in non-diabetics.
Article in BMC endocrine disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Association between glycated hemoglobin and hematological parameters in patients with type 2 diabetes mellitus: a cross-sectional study.Clinics (Sao Paulo, Brazil) · 2026Article
- Comparative Evaluation of Traditional and Emerging Glycemic Biomarkers in Diabetes.Current issues in molecular biology · 2026Review
- Influence of age on the development of stress hyperglycemia during first-onset ST-elevation myocardial infarction.Journal of diabetes investigation · 2026Article
- Review
- Association between HbA1c and red cell distribution width-standard deviation in newly diagnosed, treatment-naïve type 2 diabetes mellitus: a retrospective cross-sectional study.BMC endocrine disorders · 2026Article
- Diagnostic utility of fasting versus non-fasting blood glucose: contextualising testing strategies-a narrative review.Diabetology & metabolic syndrome · 2026Review
- Glycemic assessment when hemoglobin A1c is unreliable: a clinical-laboratory framework for kidney disease, anemia, and hemoglobinopathies.Frontiers in endocrinology · 2026Review
- Comprehensive assessment of health disparities in tribal and non-tribal population in India: a sex- and age-stratified cross-sectional study.Frontiers in public health · 2026Article
- Plasma protein GDF15 has a good predictive potential for the kidney complications of type 2 diabetes.Frontiers in endocrinology · 2026Article
- Assessment of Changes in Glycaemic Control and Blood Viscosity Determinants: Does Glycaemia Impact on Haematocrit, Proteinaemia or Dyslipidaemia?Medical sciences (Basel, Switzerland) · 2025Article
- Hemoglobin A1C in the first trimester of pregnancy as a predictor of gestational diabetes mellitus: A retrospective study in Saudi Arabia.Journal of family medicine and primary care · 2025Article
- Association Between Neck Circumference and Uncontrolled Hyperglycemia Diabetes in Korean Adults: From the Korea National Health and Nutrition Examination Survey, 2019 to 2021.Bioengineering (Basel, Switzerland) · 2025Article
- HbA1c levels in hemoglobin H disease.Biochemistry and biophysics reports · 2025Article
- Vitamin BClinical nutrition ESPEN · 2025Observational
- The Relationship of the Plasma Glycated CD59 Level with Microvascular Complications in Diabetic Patients and Its Evaluation as a Predictive Marker.Journal of clinical medicine · 2025Article
- Anemia risk and mitigation strategies in type 2 diabetic patients: The role of novel antidiabetic agents.World journal of diabetes · 2025Review
- Novel Micro-Ribonucleic Acid Biomarkers for Early Detection of Type 2 Diabetes Mellitus and Associated Complications-A Literature Review.International journal of molecular sciences · 2025Review
- Remission of type 2 diabetes mellitus: Emerging concepts and proposed diagnostic criteria.World journal of methodology · 2024Review
- Effects of weight loss from oral semaglutide administration on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a retrospective analysis using propensity score matching.Diabetology international · 2024Article
- The Effect of Iron Deficiency Anemia on Hemoglobin Glycation in Diabetics and Non-diabetics.Cureus · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is one of the most common diseases worldwide with significant morbidity and mortality. HbA1c remains one of the most important methods for diagnosis and monitoring of the disease. Since HbA1c is a reflection of the glucose attached to red blood cells, factors affecting hemoglobin and red blood cells' half-life can influence HbA1c measurements.
objectiveThis study aims to evaluate the effect of different types of anemia including iron deficiency anemia, sickle cell anemia, β -thalassemia trait, and megaloblastic anemia on HbA1c levels in a tertiary hospital over the past 6 years (2016-2022).
methodThis is a retrospective chart review study of 324 patients including those with one of the four types of anemia mentioned above and a control group. The control group were healthy adults with normal HbA1c and hemoglobin, who were not known to have diabetes or anemia. Patients with diabetes or prediabetes based on self-reporting or elevated fasting, random blood sugar, or 2 hours post-prandial blood glucose were excluded.
resultsThe mean HbA1c levels were significantly higher in sickle cell anemia at 5.83% (95% CI = 5.39-6.28) and in iron deficiency anemia at 5.75% (95% CI = 5.68-5.82) when compared to the control group at 5.32% (95% CI = 5.22-5.41). However, the mean HbA1c levels in megaloblastic anemia were 5.38% (95% CI = 5.26-5.5) and 5.45% (95% CI = 5.21-5.69) in beta thalassemia trait, which were not significantly different when compared to the control group. HbA1c significantly decreased from 5.75 to 5.44% after treatment in the iron-deficient group with a p-value of < 0.001. Moreover, lower hemoglobin and higher red cell distribution width correlated with higher HbA1c levels in patients with sickle cell anemia.
conclusionThis study found a significant increase in HbA1c levels in iron deficiency anemia and sickle cell disease in patients not known to have diabetes. However, there was no significant effect in those patients with β-thalassemia trait and megaloblastic anemia. Treatment of iron deficiency anemia significantly decreased the HbA1c level, bringing it back to normal.
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