Evidence map›Paper›PMID 36709215›Full record

SynthesisWorld journal of surgery2023

Assessment and Reporting of Perioperative Adverse Events and Complications in Patients Undergoing Inguinal Lymphadenectomy for Melanoma, Vulvar Cancer, and Penile Cancer: A Systematic Review and Meta-analysis.

Giovanni E Cacciamani, Luis G Medina, Aref S Sayegh, Anibal La Riva, Laura C Perez, Michael B Eppler, Inderbir Gill, Rene Sotelo, Complications and Adverse Events in Lymphadenectomy of the Inguinal Area (CALI) project, the International Consensus Panel on Complications in Urology (ICPCU), and the Intraoperative Complications assessment and reporting with Universal Standards (ICARUS) Global Surgical Collaboration

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giovanni E Cacciamani *Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA. Giovanni.cacciamani@med.usc.edu.
Luis G Medina *Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA.
Aref S SayeghCatherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA.
Anibal La RivaCatherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA.
Laura C PerezCatherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA.
Michael B EpplerCatherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA.
Inderbir GillCatherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA.
Rene SoteloCatherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine,, University of Southern California, Los Angeles, CA, USA. rene.sotelo@med.usc.edu.ORCID 0000-0002-8580-8476
Complications and Adverse Events in Lymphadenectomy of the Inguinal Area (CALI) project, the International Consensus Panel on Complications in Urology (ICPCU), and the Intraoperative Complications assessment and reporting with Universal Standards (ICARUS) Global Surgical Collaboration
University of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInguinal lymph node dissection (ILND) plays a crucial role in the oncological management of patients with melanoma, penile, and vulvar cancer. This study aims to systematically evaluate perioperative adverse events (AEs) in patients undergoing ILND and its reporting.

methodsA systematic review was conducted according to PRISMA. PubMed, MEDLINE, Scopus, and Embase were queried to identify studies discussing perioperative AEs in patients with melanoma, penile, and vulvar cancer following ILND.

resultsOur search generated 3.469 publications, with 296 studies meeting the inclusion criteria. Details of 14.421 patients were analyzed. Of these studies, 58 (19.5%) described intraoperative AEs (iAEs) as an outcome of interest. Overall, 68 (2.9%) patients reported at least one iAE. Postoperative AEs were reported in 278 studies, combining data on 10.898 patients. Overall, 5.748 (52.7%) patients documented ≥1 postoperative AEs. The most reported ILND-related AEs were lymphatic AEs, with a total of 4.055 (38.8%) events. The pooled meta-analysis confirmed that high BMI (RR 1.09; p = 0.006), ≥1 comorbidities (RR 1.79; p = 0.01), and diabetes (RR 1.81; p =  < 0.00001) are independent predictors for any AEs after ILND. When assessing the quality of the AEs reporting, we found 25% of studies reported at least 50% of the required criteria.

conclusionILND performed in melanoma, penile, and vulvar cancer patients is a morbid procedure. The quality of the AEs reporting is suboptimal. A more standardized AEs reporting system is needed to produce comparable data across studies for furthering the development of strategies to decrease AEs.

Indexed as

Lymphatic VesselsMelanomaPenile NeoplasmsVulvar NeoplasmsFemaleHumansLymph Node ExcisionMale

Identifiers

PMID36709215
OpenAlexW4318381708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.