Evidence map›Paper›PMID 36709083›Full record

ReviewTrends in immunology2023

COVID-19 vaccines and a perspective on Africa.

Alberto Mantovani, Maria Rescigno, Guido Forni, Francesca Tognon, Giovanni Putoto, Jerry Ictho, Peter Lochoro

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alberto MantovaniIRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; William Harvey Research Institute, Queen Mary University, London EC1M 6BQ, UK. Electronic address: alberto.mantovani@humanitasresearch.it.
Maria RescignoIRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy.
Guido ForniAccademia Nazionale dei Lincei, Rome, Italy.
Francesca TognonOperational Research Unit, Doctors with Africa CUAMM, Italy.
Giovanni PutotoHead of Planning and Operational Research, Doctors with Africa CUAMM, Italy.
Jerry IcthoClinical Epidemiology, Doctors with Africa CUAMM, Uganda.
Peter LochoroHealth Service Management, Doctors with Africa CUAMM, Uganda. Electronic address: p.lochoro@cuamm.org.
Doctors with Africa Cuamm · ITHumanitas University · ITAccademia Nazionale dei Lincei · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines have dramatically changed the COVID-19 pandemic. Over 30 vaccines that were developed on four main platforms are currently being used globally, but a deep dissection of the immunological mechanisms by which they operate is limited to only a few of them. Here, we review the evidence describing specific aspects of the modes of action of COVID-19 vaccines; these include innate immunity, trained innate immunity, and mucosal responses. We also discuss the use of COVID-19 vaccines in the African continent which is ridden with inequality in its access to vaccines and vaccine-related immunological research. We argue that strengthening immunology research in Africa should inform on fundamental aspects of vaccination, including the relevance of genetics, trained innate immunity, and microbiome diversity.

Indexed as

COVID-19VaccinesCOVID-19 VaccinesHumansImmunity, InnatePandemicsVaccinationCOVID-19 VaccinesVaccinesAfricaCOVID-19immune imprintinginnate immunitylong COVIDmucosal responsestrained immunityvaccine inequalityvaccines

Identifiers

PMID36709083
PMCPMC9832054
OpenAlexW4315649081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.