Evidence map›Paper›PMID 36708980›Full record

ArticleMolecular and cellular endocrinology2023

Developmental programming: Adipose depot-specific regulation of non-coding RNAs and their relation to coding RNA expression in prenatal testosterone and prenatal bisphenol-A -treated female sheep.

John Dou, Soundara Viveka Thangaraj, Muraly Puttabyatappa, Venkateswaran Ramamoorthi Elangovan, Kelly Bakulski, Vasantha Padmanabhan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

John DouDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Soundara Viveka ThangarajDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Muraly PuttabyatappaDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Venkateswaran Ramamoorthi ElangovanDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Kelly BakulskiDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA. Electronic address: bakulski@umich.edu.
Vasantha PadmanabhanDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA. Electronic address: vasantha@umich.edu.
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
STEROIDAL AND METABOLIC MEDIATION OF NEUROENDOCRINE CIRCUITRYP01HD044232 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA · 2004 to 2015
$12.9M
ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
Multigenerational Effects of Gestational Testosterone ExcessR01HD099096 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARDOSO, RODOLFO C., PADMANABHAN, VASANTHA · 2020 to 2024
$2.6M
Transgenerational consequences of pre-conceptional and in utero exposure to real-life chemical mixtures on fertility and metabolic healthR01ES030374 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EVANS, NEIL PRICE, LEA, RICHARD · 2020 to 2024
$2.3M
Bisphenol-A and Reproductive DysfunctionR01ES016541 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA · 2009 to 2013
$2.0M
NICHD NIH HHS P01 HD044232NICHD NIH HHS R01 HD099096NIDDK NIH HHS P30 DK020572NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES016541NIEHS NIH HHS R01 ES030374NIEHS NIH HHS T32 ES007062
6 · The paper itself

Abstract

Inappropriate developmental exposure to steroids is linked to metabolic disorders. Prenatal testosterone excess or bisphenol A (BPA, an environmental estrogen mimic) leads to insulin resistance and adipocyte disruptions in female lambs. Adipocytes are key regulators of insulin sensitivity. Metabolic tissue-specific differences in insulin sensitivity coupled with adipose depot-specific changes in key mRNAs, were previously observed with prenatal steroid exposure. We hypothesized that depot-specific changes in the non-coding RNA (ncRNA) - regulators of gene expression would account for the direction of changes seen in mRNAs. Non-coding RNA (lncRNA, miRNA, snoRNA, snRNA) from various adipose depots of prenatal testosterone and BPA-treated animals were sequenced. Adipose depot-specific changes in the ncRNA that are consistent with the depot-specific mRNA expression in terms of directionality of changes and functional implications in insulin resistance, adipocyte differentiation and cardiac hypertrophy were found. Importantly, the adipose depot-specific ncRNA changes were model-specific and mutually exclusive, suggestive of different regulatory entry points in this regulation.

Indexed as

Insulin ResistancePrenatal Exposure Delayed EffectsAnimalsBisphenol A CompoundsFemaleHumansObesityPregnancyRNA, UntranslatedSheepSteroidsTestosteronebisphenol ABisphenol A CompoundsRNA, UntranslatedSteroidsTestosteroneEndocrine disruptorsFetal programmingInsulin resistanceRNA sequencingSteroids

Identifiers

PMID36708980
PMCPMC10069610
OpenAlexW4318065098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.