ArticleNeuron2023
Oxytocin receptor is not required for social attachment in prairie voles.
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Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 95 citations in OpenAlex.
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- Advancing insights into the neuroendocrine basis of socio-sexual interactions in mammals.Endocrinology · 2026Review
- Hypothalamic subunit volumes and relations to violence and psychopathy in male offenders with or without a psychotic disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- A Demographic History of a Prairie Vole (bioRxiv : the preprint server for biology · 2026Article
- Paternal Deprivation Alters Neural Stem Cells Proliferation and Epigenetic Histone Modifications in the Neurogenic Niches of Adult Prairie Voles.International journal of molecular sciences · 2026Article
- Study on the cognitive effects of eye movement desensitization and reprocessing: proposed active mechanisms.Frontiers in computational neuroscience · 2026Article
- The prairie vole gut-brain-microbiota-axis: a narrative review.Gut microbiome (Cambridge, England) · 2026Review
- Romantic love as regulatory co-option of maternal-bonding circuitry: a testable genetic account.Frontiers in behavioral neuroscience · 2026Article
- Natural variation in the oxytocin receptor gene predicts social observation in female prairie voles.bioRxiv : the preprint server for biology · 2025Article
- Oxytocin receptors mediate social selectivity in prairie vole peer relationships.Current biology : CB · 2025Article
- An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles.Hormones and behavior · 2025Article
- LinkedbioRxiv : the preprint server for biology · 2025Article
- Review
- Neural connectivity of oxytocin receptor-expressing neurons in the nucleus accumbens and their role in social attachment.Hormones and behavior · 2025Article
- The paraventricular nucleus of the hypothalamus: a key node in the control of behavioural states.The Journal of physiology · 2025Review
- The barn owl in systems and behavioral neuroscience: Progress and promise.Current opinion in neurobiology · 2025Review
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
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Authors and funding
18 authors at 5 institutions in 1 country.
Kristen M BerendzenDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Ruchira SharmaDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Maricruz Alvarado MandujanoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Yichao WeiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Forrest D RogersDepartment of Psychology, University of California, Davis, Davis, CA, USA.
Trenton C SimmonsDepartment of Psychology, University of California, Davis, Davis, CA, USA.
Adele M H SeelkeDepartment of Psychology, University of California, Davis, Davis, CA, USA.
Jessica M BondDepartment of Psychology, University of California, Davis, Davis, CA, USA.
Rose LariosDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 95158, USA.
Nastacia L GoodwinDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Michael ShermanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Srinivas ParthasarthyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Isidero EspinedaDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Joseph R KnoedlerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Annaliese BeeryDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Karen L BalesDepartment of Psychology, University of California, Davis, Davis, CA, USA; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA 95616, USA.
Nirao M ShahDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: nirao@stanford.edu.
Devanand S ManoliDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA. Electronic address: devanand.manoli@ucsf.edu.
University of California, San Francisco · USUniversity of California, Davis · USStanford University · USStanford Medicine · USUniversity of California, Berkeley · US
Funding
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9MTRAINING THE NEXT GENERATION OF MENTAL HEALTH RESEARCHERSR25MH060482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H MATHALON, Susan M. Voglmaier · 2000 to 2026
$5.2MUnderstanding the neural basis of social attachmentR01MH123513 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANOLI, DEVANAND SADANAND · 2020 to 2024
$3.3MMolecular and Neural Networks Underlying Social AttachmentR01MH108319 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALES, KAREN L., SHAH, NIRAO MAHESH · 2016 to 2020
$3.1MDissecting the neural control of social attachmentDP1MH099900 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHAH, NIRAO MAHESH · 2012 to 2013
$1.5MGenetic models for social attachment deficits in psychiatric illnessK08MH107754 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANOLI, DEVANAND SADANAND · 2016 to 2019
$737kNIA NIH HHS P30 AG062422NIMH NIH HHS DP1 MH099900NIMH NIH HHS K08 MH107754NIMH NIH HHS R01 MH108319NIMH NIH HHS R01 MH123513NIMH NIH HHS R25 MH060482
Abstract
Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines. Oxtr mutants displayed social attachment such that males and females showed a behavioral preference for their mating partners over a stranger of the opposite sex, even when assayed using different experimental setups. Mothers lacking Oxtr delivered viable pups, and parents displayed care for their young and raised them to the weanling stage. Together, our studies unexpectedly reveal that social attachment, parturition, and parental behavior can occur in the absence of Oxtr signaling in prairie voles.
Indexed as
GrasslandReceptors, OxytocinAnimalsArvicolinaeFemaleMaleMammalsOxytocinSocial BehaviorOxytocinReceptors, OxytocinCRISPRmonogamynursingoxytocin receptorpair-bondingparental behaviorpartner preferenceprairie volesocial attachment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.