Evidence map›Paper›PMID 36708677›Full record

ArticleEuropean journal of medicinal chemistry2023

Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB

Toni Kline, Cong Xu, Faith R Kreitzer, Dow P Hurst, Khalil M Eldeeb, Jim Wager-Miller, Kathleen Olivas, Seon A Hepburn, John W Huffman, Ken Mackie and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Toni KlineDepartment of Microbiology, University of Washington, Seattle, WA, 98195, USA.
Cong XuDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA.
Faith R KreitzerDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA.
Dow P HurstDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, NC, 27412, USA.
Khalil M EldeebDepartment of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, NC, 27157, USA.
Jim Wager-MillerDepartment of Psychological and Brain Sciences and the Gill Center, Indiana University, Bloomington, IN, 47405, USA.
Kathleen OlivasDepartment of Microbiology, University of Washington, Seattle, WA, 98195, USA.
Seon A HepburnHoward L. Hunter Laboratory, Clemson University, Clemson, SC, 29634, USA.
John W HuffmanHoward L. Hunter Laboratory, Clemson University, Clemson, SC, 29634, USA.
Ken MackieDepartment of Psychological and Brain Sciences and the Gill Center, Indiana University, Bloomington, IN, 47405, USA.
Allyn C HowlettDepartment of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, NC, 27157, USA.
Patricia ReggioDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, NC, 27412, USA.
Nephi StellaDepartment of Pharmacology, University of Washington, Seattle, WA, 98195, USA; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA, 98195, USA. Electronic address: nstella@uw.edu.
University of Washington · USClemson University · USIndiana University Bloomington · USUniversity of North Carolina at Greensboro · USWake Forest University · US

Funding

Cannabinoid Receptors and Associated Proteins-RenewalR01DA042157 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLYN C HOWLETT, W TODD LOWTHER · 2017 to 2026
$5.4M
Neuronal cannabinoidsR01DA011322 · NIDA · UNIVERSITY OF WASHINGTON · PI MACKIE, KENNETH · 1998 to 2014
$3.4M
Differential response of glioblastomas to microtubule targeting agentsR01CA244213 · NCI · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2020 to 2024
$1.5M
SYNTHESIS OF CANNABINOIDS, ANALOGUES, AND METABOLITESR01DA003590 · NIDA · CLEMSON UNIVERSITY · PI HUFFMAN, JOHN W · 1985 to 2009
$1.5M
Cannabinoid Modulation of Cell FunctionK05DA021696 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI MACKIE, KENNETH · 2007 to 2017
$1.3M
Senior Scientist Award: Molecular Determinants for Cannabinoid ActivityK05DA021358 · NIDA · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI REGGIO, PATRICIA HODAPP · 2007 to 2016
$1.3M
Novel CB ReceptorsR01DA021285 · NIDA · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2007 to 2010
$1.2M
Novel microtubule-targeting agents for the treatment of glioblastoma multiformR21NS106924 · NINDS · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2018 to 2019
$411k
NCI NIH HHS R01 CA244213NIDA NIH HHS K05 DA021358NIDA NIH HHS K05 DA021696NIDA NIH HHS R01 DA003590NIDA NIH HHS R01 DA011322NIDA NIH HHS R01 DA021285NIDA NIH HHS R01 DA042157NINDS NIH HHS R21 NS106924
6 · The paper itself

Abstract

The alkylindole (AI), WIN55212-2, modulates the activity of several proteins, including cannabinoid receptors 1 and 2 (CB

Indexed as

CannabinoidsBenzoxazinesGuanosine 5'-O-(3-Thiotriphosphate)HEK293 CellsHumansMorpholinesNaphthalenesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidReceptors, G-Protein-Coupled(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneBenzoxazinesCannabinoidsGuanosine 5'-O-(3-Thiotriphosphate)MorpholinesNaphthalenesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidReceptors, G-Protein-CoupledAlkylindolesCannabinoidsG protein-coupled receptors

Identifiers

PMID36708677
PMCPMC10917149
OpenAlexW4318450038

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.