Evidence map›Paper›PMID 36708623›Full record

ReviewSchizophrenia research2023

Within-individual variability in cognitive performance in schizophrenia: A narrative review of the key literature and proposed research agenda.

Olivia Wootton, Shareefa Dalvie, Ezra Susser, Ruben C Gur, Dan J Stein

Open access · greenAbstract readReview
In one paragraph

Review in Schizophrenia research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Olivia WoottonDepartment of Psychiatry and Mental Health, University of Cape Town, South Africa. Electronic address: wttoli001@myuct.ac.za.
Shareefa DalvieDepartment of Psychiatry and Mental Health, University of Cape Town, South Africa; Biomedical Research and Innovation Platform, South African Medical Research Council, South Africa.
Ezra SusserDepartment of Epidemiology, Mailman School of Public Health, Columbia University, USA; New York State Psychiatric Institute, New York, NY, USA.
Ruben C GurBrain Behavior Laboratories, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, USA.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, South Africa; SAMRC Unit on Risk & Resilience in Mental Disorders, South Africa.
South African Medical Research Council · ZANew York Psychoanalytic Society and Institute · USUniversity of Cape Town · ZAUniversity of Pennsylvania · US

Funding

3/3 Genomics of Schizophrenia in the South African XhosaU01MH125053 · NIMH · UNIVERSITY OF CAPE TOWN · PI STEIN, DAN JOSEPH · 2021 to 2025
$3.5M
The Ancestral Populations Network Phenotypic Harmonization Working Group Administrative Supplement: 2/3 Genomics of Schizophrenia in the South African XhosaU01MH125058 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WALL, MELANIE M · 2021 to 2025
$2.5M
NIMH NIH HHS U01 MH125053NIMH NIH HHS U01 MH125058
6 · The paper itself

Abstract

Schizophrenia is a neurodevelopmental disorder and a leading cause of disability worldwide. Deficits in cognitive function are characteristic of schizophrenia and are predictors of functional outcomes in the disorder. Within-individual variability (WIV) in cognitive performance is elevated in schizophrenia and has been suggested to provide additional insight into cognitive function over and above mean performance measures. Despite growing interest in WIV in schizophrenia, research on the clinical significance and neural correlates of WIV in the disorder remains sparse. The present narrative review summarizes the key literature linking WIV in schizophrenia to clinical, neural, and genetic correlates. Here, we aim to highlight key knowledge gaps and provide directions for future research into WIV in schizophrenia.

Indexed as

Cognition DisordersSchizophreniaCognitionHumansCognitionGenetic predisposition to diseaseNeuroimagingReaction timeSchizophreniaWithin-individual variability

Identifiers

PMID36708623
PMCPMC9974859
OpenAlexW4318449993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.