Evidence map›Paper›PMID 36708583›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Profiling the Expression and Prognostic Values of FYN, A Non-Receptor Tyrosine Kinase, in Different Histological Types of Epithelial Ovarian Cancer.

Wiyada Dankai, Surapan Khunamornpong, Prapaporn Suprasert, Suree Lekawanvijit

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wiyada DankaiDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0003-3914-1604
Surapan KhunamornpongDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0002-5442-0188
Prapaporn SuprasertDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0002-0205-2280
Suree LekawanvijitDepartment of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID 0000-0002-5488-8119
Chiang Mai University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was aimed at evaluating FYN expression among different histologic types of epithelial ovarian cancer (EOC) and its associated prognostics.

methodsThe FYN expression levels using quantitative real-time PCR method were evaluated in 98 primary EOC. Receiver operating characteristic curve were used to select an optimal cut-off value for determining the presence or absence of a disease progression.

resultThe median level of FYN expression varied among different EOC types, being the highest in high-grade serous carcinomas and the lowest in clear cell carcinomas (CCC). Using the cutoff FYN value to predict disease progression, the FYN-positive group had a poorer progression-free survival (PFS) compared to the FYN-negative group (p = 0.001). In multivariate Cox regression analysis, FYN expression was an independent predictor for disease progression (Hazard ratio = 2.30; 95% CI: 1.21- 4.38; p = 0.011). In subgroup analysis, FYN expression was significantly associated with lower PFS in early stage CCC patients (p = 0.009).

conclusionFYN expression is variable among different types of EOC while impacting on the prognostic values in patients with early stage CCC.

Indexed as

Ovarian NeoplasmsBiomarkers, TumorCarcinoma, Ovarian EpithelialDisease ProgressionFemaleHumansPrognosisProtein-Tyrosine KinasesProto-Oncogene Proteins c-fynBiomarkers, TumorFYN protein, humanProtein-Tyrosine KinasesProto-Oncogene Proteins c-fynclear cell carcinomasdisease progressionFynnon-receptor tyrosine kinase proteinOvarian Cancer

Identifiers

PMID36708583
PMCPMC10152874
OpenAlexW4318387629

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.