Evidence map›Paper›PMID 36708580›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Immunological Study of IFN-γ, ICAM-4, and Vitamin D3 Markers among Gastrointestinal Tumor Patients in Babylon Province, Iraq.

Ali Husain Shilib Al-Shimmery, Zena Abdul-Ameer Mahdi, Hayder Abdul-Amir Makki Al-Hindy, Raheem Tuama Obayes Al-Mammori, Thanaa Abdulmahdi Mokif, Hussein O M Al-Dahmoshi, Noor S K Al-Khafaji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Emerging perspectives: unraveling the anticancer potential of vitamin DNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ali Husain Shilib Al-ShimmeryBabylon GIT Center, Babylon, Hilla City, Iraq.
Zena Abdul-Ameer MahdiCollege of Pharmacy, Ahl Al Bayt University, Karbala, Iraq.
Hayder Abdul-Amir Makki Al-HindyDepartment of Pharmacology & Toxicology, College of Pharmacy, University of Babylon, Babylon, Iraq.
Raheem Tuama Obayes Al-MammoriBabylon GIT and Liver Center, Babylon Health Directorate, Hilla, Iraq.
Thanaa Abdulmahdi MokifBabylon Technical Institute, Al-Furat Al-Awsat Technical University, 51015 Babylon, Iraq.
Hussein O M Al-DahmoshiDepartment of Biology, College of Science, University of Babylon, Hilla, Iraq.
Noor S K Al-KhafajiDepartment of Biology, College of Science, University of Babylon, Hilla, Iraq.
University of Babylon · IQAhl Al Bayt University · IQAl-Furat Al-Awsat Technical University · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe current study was conducted to investigate the roles of ICAM-4, IFN-γ, and vitamin D3 markers among benign and malignant gastrointestinal stromal tumors (GISTs). METHODOLOGY: Eighty-eight participants, admitted to the Babylon GIT Center, Merjan Medical City, Iraq from April to December 2020, were recruited for the study. Blood samples were collected from the participants, who were divided into four groups: malignant GIT tumor (N = 42), benign GIT tumor (N = 29), irritable bowel disease as a positive control (N = 10), and healthy individuals as a negative control (N = 7). Serum ICAM-4, IFN-γ, and vitamin D3 levels were determined using the blood samples.

resultsThe younger males were more affected by malignant GIT tumors at a mean age of 53.39 years than benign GIT tumors, IBD, and healthy individuals. There is also an increase in ICAM-4, IFN-γ, and a decrease in vitamin D3 levels compared to healthy individuals. The vitamin D3 level decreased progressively with age and rose in ICAM-4 with a decrease in vitamin D3 level in patients, increasing the probability of infection with GIT tumor. ICAM-4 levels may grow and increase as interferon levels rise.

conclusionThe younger males are more prone to malignant GIT and the serum levels of ICAM-4, vitamin D3, and IFN-γ are high in malignant patients compared with benign GIT tumors and lower than the control.

Indexed as

CholecalciferolGastrointestinal NeoplasmsCell Adhesion MoleculesHumansInterferon-gammaIraqMaleMiddle AgedCell Adhesion MoleculesCholecalciferolICAM4 protein, humanInterferon-gammaGastrointestinal stromal tumorsGIT tumorICAM-4IFN-γVitamin D

Identifiers

PMID36708580
PMCPMC10152847
OpenAlexW4318387352

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.