Evidence map›Paper›PMID 36708557›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Genetic Polymorphisms in ERCC1 Gene and Their Association with Response to Radiotherapy in Moroccan Patients with Nasopharyngeal Carcinoma.

Rajaa Benzeid, Amina Gihbid, Nezha Tawfiq, Nadia Benchakroun, Karima Bendahhou, Abdelatif Benider, Amal Guensi, Naima El Benna, Abdelkarim Filali Maltouf, Mohammed Attaleb and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Rajaa BenzeidBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.ORCID 0000-0003-0967-0898
Amina GihbidLaboratory of Viral Oncology, Institut Pasteur du Maroc, Casablanca, Morocco.ORCID 0000-0002-1958-0688
Nezha TawfiqMohammed VI Center for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Nadia BenchakrounMohammed VI Center for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Karima BendahhouMohammed VI Center for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Abdelatif BeniderMohammed VI Center for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Amal GuensiNuclear Medecine Department, Ibn Rochd University Hospital, Hassan II University, Casablanca, Morocco.
Naima El BennaDepartment of Radiology, Ibn Rochd University Hospital, Hopital 20 Août, Casablanca, Morocco.
Abdelkarim Filali MaltoufLaboratory of Microbiology and Molecular Biology, Faculty of Sciences, Rabat, Morocco.
Mohammed AttalebBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Imane ChaouiBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Meriem KhyattiLaboratory of Viral Oncology, Institut Pasteur du Maroc, Casablanca, Morocco.ORCID 0000-0001-9376-4322
Mohammed El MzibriBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.ORCID 0000-0002-3148-1527
Centre Hospitalier Universitaire Ibn Rochd · MANational Centre for Nuclear Energy, Science and Technology · MAInstitut Pasteur du Maroc · MAMohammed V University · MAHôpital 20 Août · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNasopharyngeal carcinoma (NPC) is a severe malignant disease. Despite its low frequency, NPC is very common in North African population. Radiotherapy is the standard therapeutic treatment of NPC. However, radioresistance hampers the success of treatment. At the molecular scale, radioresistance is due to genetic variations involved in DNA repair pathways in NPC patients. Several studies reported that single nucleotide polymorphisms (SNPs) in excision repair cross complementing group 1 (ERCC1) could be associated with radioresistance. In this optic, the present study aimed to evaluate the association between DNA repair gene polymorphisms ERCC1 C8092A and ERCC1 C118T and radiotherapy response of patients with NPC.

methodsA total of 95 patients with confirmed NPC were recruited at the Mohammed VI Center for Cancer Treatment, Casablanca - Morocco between 2016 and 2018. Two single nucleotide polymorphisms in ERCC1 gene were genotyped. Multiple analysis software was used to assess the correlation between these SNPs and radio-therapeutic response.

resultsSequencing of ERCC1 C8092A polymorphism revealed that CC and CA genotypes were found in 51.6% and 45.3% of cases, respectively, whereas the homozygote AA genotype was reported in only 3.1% of cases. For ERCC1 C118T polymorphism, the heterozygote CT genotype was identified in 49.5% of cases. Homozygotes genotypes CC and TT were detected in 17.9% and 32.6% respectively of NPC cases. Of note, no significant association was found between the ERCC1 C8092A polymorphism and response to radiation therapy (p=0.81). Similarly, there was no significant association between the response to radiotherapy and allelic distribution (p=0.56). Likewise, no correlation was observed neither with genotypes (p=0.07) nor with alleles (p=0.09) of ERCC1 C118T polymorphism and response to radiation therapy.

conclusionOur results clearly showed that ERCC1 C8092A and ERCC1 C118T polymorphisms were not associated with response to radiotherapy in Moroccan NPC patients. Large studies are warranted to confirm the role of these SNPs in therapeutic response of NPC patients.

Indexed as

DNA-Binding ProteinsNasopharyngeal NeoplasmsEndonucleasesGenotypeHumansNasopharyngeal CarcinomaPolymorphism, Single NucleotideDNA-Binding ProteinsEndonucleasesERCC1 protein, humanERCC1 C118TERCC1 C8092AMoroccoNasopharyngeal carcinomaRadioresistance

Identifiers

PMID36708557
PMCPMC10152845
OpenAlexW4318450970

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.