Evidence map›Paper›PMID 36708485›Full record

ArticleFamilial cancer2023

Heritable methylation marks associated with prostate cancer risk.

James G Dowty, Chenglong Yu, Mahnaz Hosseinpour, Jihoon Eric Joo, Ee Ming Wong, Tu Nguyen-Dumont, Joseph Rosenbluh, Graham G Giles, Roger L Milne, Robert J MacInnis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Familial cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Non-coding 886 (Epigenetics · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

James G DowtyCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3010, Parkville, VIC, Australia.
Chenglong YuPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, 3168, Clayton, VIC, Australia.
Mahnaz HosseinpourPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, 3168, Clayton, VIC, Australia.
Jihoon Eric JooDepartment of Clinical Pathology, Melbourne Medical School, The University of Melbourne, 3010, Parkville, VIC, Australia.
Ee Ming WongPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, 3168, Clayton, VIC, Australia.
Tu Nguyen-DumontPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, 3168, Clayton, VIC, Australia.
Joseph RosenbluhCancer Research Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, 3800, Clayton, VIC, Australia.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3010, Parkville, VIC, Australia.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3010, Parkville, VIC, Australia.
Robert J MacInnisCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3010, Parkville, VIC, Australia.
Pierre-Antoine DuguéCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 3010, Parkville, VIC, Australia.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, 3168, Clayton, VIC, Australia. melissa.southey@monash.edu.

Funding

Prostate Cancer Foundation of Australia NCG-0716
6 · The paper itself

Abstract

DNA methylation marks that are inherited from parents to offspring are known to play a role in cancer risk and could explain part of the familial risk for cancer. We therefore conducted a genome-wide search for heritable methylation marks associated with prostate cancer risk. Peripheral blood DNA methylation was measured for 133 of the 469 members of 25 multiple-case prostate cancer families, using the EPIC array. We used these families to systematically search the genome for methylation marks with Mendelian patterns of inheritance, then we tested the 1,000 most heritable marks for association with prostate cancer risk. After correcting for multiple testing, 41 heritable methylation marks were associated with prostate cancer risk. Separate analyses, based on 869 incident cases and 869 controls from a prospective cohort study, showed that 9 of these marks near the metastable epiallele VTRNA2-1 were also nominally associated with aggressive prostate cancer risk in the population.

Indexed as

DNA MethylationProstatic NeoplasmsEpigenesis, GeneticHumansInheritance PatternsMaleProspective StudiesAggressive prostate cancerDNA methylationFamilial prostate cancerHeritable methylation marksProstate cancer riskTrans-generational inheritance

Identifiers

PMID36708485
PMCPMC10275808

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.