Evidence map›Paper›PMID 36708397›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2023

Conditional survival after surgery for metastatic tumors of the spine: does prognosis change over time?

Nikita Zaborovskii, Adam Schlauch, John Shapton, Anton Denisov, Dmitrii Ptashnikov, Dmitrii Mikaylov, Sergei Masevnin, Oleg Smekalenkov, Vladislav Murakhovsky, Dimitriy Kondrashov

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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Nikita ZaborovskiiVreden National Medical Research Center of Traumatology and Orthopedics, Saint-Petersburg, Russia.
Adam SchlauchSan Francisco Orthopaedic Residency Program/ Saint Mary's Medical Center, San Francisco, CA, USA.
John ShaptonSan Francisco Orthopaedic Residency Program/ Saint Mary's Medical Center, San Francisco, CA, USA.
Anton DenisovTraumatología Elgeadi/Hospital Quirónsalud Valle del Henares, Madrid, Spain.
Dmitrii PtashnikovVreden National Medical Research Center of Traumatology and Orthopedics, Saint-Petersburg, Russia.
Dmitrii MikaylovVreden National Medical Research Center of Traumatology and Orthopedics, Saint-Petersburg, Russia.
Sergei MasevninVreden National Medical Research Center of Traumatology and Orthopedics, Saint-Petersburg, Russia.
Oleg SmekalenkovVreden National Medical Research Center of Traumatology and Orthopedics, Saint-Petersburg, Russia.
Vladislav MurakhovskyVreden National Medical Research Center of Traumatology and Orthopedics, Saint-Petersburg, Russia.
Dimitriy KondrashovSan Francisco Orthopaedic Residency Program/ Saint Mary's Medical Center, San Francisco, CA, USA. sfspine@gmail.com.ORCID 0000-0002-3390-6648
Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden · RUSt. Mary's Medical Center · USResearch Institute Hospital 12 de Octubre · ESSt Petersburg University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeConditional survival (CS) provides a dynamic prediction of patient survival by incorporating the time an individual has already survived given their disease specific characteristics. The objective of the current study was to estimate CS among patients after surgery for spinal cord compression or spinal instability, as well as stratify CS according to relevant patient- and disease-related characteristics.

methodsThe clinical outcomes of 361 patients undergoing surgical management of metastatic spinal tumors were retrospectively analyzed. Stratification of this cohort according to disease and surgery-specific characteristics allowed for univariate and multivariate statistical analyses of our study population. Observed overall and conditional survival estimates were calculated by the Kaplan-Meier method.

results12-month conditional survival in patients undergoing surgical management of metastatic spine tumors increased from 57% at baseline to 70% at 24 months following spine surgery. Overall survival (OS) was influenced by CCI grade, Katagiri tumor type, presence of lung metastasis, type of spine surgery, presence of postoperative systemic therapy and ambulatory status at follow-up. Analyses of OS and CS by prognostic strata were similar with exception of stratification by surgery type. Differences in survival between strata tend to converge over time. Unfavorable factors for OS appear to be less relevant after a period of 24 months following spine surgery.

conclusionPatients after surgery for metastatic tumors of the spine can expect a positive trend in conditional survival as survivorship increases. Even patients with a more severe disease can be encouraged with gains in conditional survival over time. LEVEL OF EVIDENCE: Level IV (retrospective cohort study).

Indexed as

Lung NeoplasmsSpinal Cord CompressionHumansPrognosisRetrospective StudiesSpineConditional survivalMetastasisOverall survivalPrognostic factorsSpine

Identifiers

PMID36708397
OpenAlexW4318338067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.