ReviewBrain structure & function2023
Evolving characterization of the human hyperdirect pathway.
Review in Brain structure & function, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Cortical Contributions to Attentional Orienting and Response Cancellation in Action Stopping.Psychophysiology · 2026Article
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- Hyperdirect projections from the supplementary motor area mediate subthalamic stimulation effects on movement initiation and inhibition in Parkinson's disease.Brain communications · 2026Article
- Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases.Annals of neurology · 2025Review
- Stopping Muscle Contractions and Relaxations during Action Inhibition Involves Global and Targeted Control Dependent on Muscle State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- When Stopping Requires Going: Physiological Similarities Between Action Cancellation and the Cancellation of Action Cancellation.The European journal of neuroscience · 2025Article
- Neuroanatomical Changes in the Stopping Network Across the Adult Lifespan Assessed With Quantitative and Diffusion MRI.Human brain mapping · 2025Article
- Reduced recruitment of inhibitory control regions in very young children with ADHD during a modified Kiddie Continuous Performance Task: A fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- The human subthalamic nucleus transiently inhibits active attentional processes.Brain : a journal of neurology · 2024Article
- Coupled Activation of the Hyperdirect and Cerebellothalamic Pathways with Zona Incerta Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- The onset of motor learning impairments in Parkinson's disease: a computational investigation.Brain informatics · 2024Article
- Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans.Frontiers in neural circuits · 2024Article
- Neural mechanisms of domain-general inhibitory control.Trends in cognitive sciences · 2023Review
- Programming of subthalamic nucleus deep brain stimulation with hyperdirect pathway and corticospinal tract-guided parameter suggestions.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The hyperdirect pathway (HDP) represents the main glutamatergic input to the subthalamic nucleus (STN), through which the motor and prefrontal cerebral cortex can modulate basal ganglia activity. Further, direct activation of the motor HDP is thought to be an important component of therapeutic deep brain stimulation (DBS), mediating the disruption of pathological oscillations. Alternatively, unintended recruitment of the prefrontal HDP may partly explain some cognitive side effects of DBS therapy. Previous work describing the HDP has focused on non-human primate (NHP) histological pathway tracings, diffusion-weighted MRI analysis of human white matter, and electrophysiology studies involving paired cortical recordings with DBS. However, none of these approaches alone yields a complete understanding of the complexities of the HDP. As such, we propose that generative modeling methods hold promise to bridge anatomy and physiology results, from both NHPs and humans, into a more detailed representation of the human HDP. Nonetheless, numerous features of the HDP remain to be experimentally described before model-based methods can simulate corticosubthalamic activity with a high degree of scientific detail. Therefore, the goals of this review are to examine the experimental evidence for HDP projections from across the primate neocortex and discuss new data which are required to improve the utility of anatomical and biophysical models of the human corticosubthalamic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.