Evidence map›Paper›PMID 36708289›Full record

ArticleJournal of anatomy2023

Embryonic and skeletal development of the albino African clawed frog (Xenopus laevis).

Zhixin Shan, Shanshan Li, Chenghua Yu, Shibin Bai, Junpeng Zhang, Yining Tang, Yutong Wang, David M Irwin, Jun Li, Zhe Wang

Open access · greenAbstract read
In one paragraph

Article in Journal of anatomy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Zoological research · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zhixin ShanCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
Shanshan LiCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
Chenghua YuDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Shibin BaiCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.ORCID 0000-0002-0218-8524
Junpeng ZhangCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
Yining TangCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
Yutong WangCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
David M IrwinDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Jun LiDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Zhe WangCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
Shenyang Agricultural University · CNChina Medical University · CNUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The normal stages of embryonic development for wild-type Xenopus laevis were established by Nieuwkoop and Faber in 1956, a milestone in the history of understanding embryonic development. However, this work lacked photographic images and staining for skeleton structures from the corresponding stages. Here, we provide high-quality images of embryonic morphology and skeleton development to facilitate studies on amphibian development. On the basis of the classical work, we selected the albino mutant of X. laevis as the observation material to restudy embryonic development in this species. The lower level of pigmentation makes it easier to interpret histochemical experiments. At 23°C, albino embryos develop at the same rate as wild-type embryos, which can be divided into 66 stages as they develop into adults in about 58 days. We described the complete embryonic development system for X. laevis, supplemented with pictures of limb and skeleton development that are missing from previous studies, and summarized the characteristics and laws of limb and skeleton development. Our study should aid research into the development of X. laevis and the evolution of amphibians.

Indexed as

Embryonic DevelopmentOrganogenesisAnimalsXenopus laevisembryonic developmentskeletal developmentskeleton stainingXenopus laevis

Identifiers

PMID36708289
PMCPMC10184547
OpenAlexW4318393733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.