Evidence map›Paper›PMID 36708275›Full record

ArticleInternational wound journal2023

Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers.

David G Armstrong, Michael E Edmonds, Thomas E Serena

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in International wound journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Observational
  5. A Scoping Review of Fluorescence Imaging: A Promising New Technology for Bacterial Detection in Burn Wounds.Journal of burn care & research : official publication of the American Burn Association · 2026
    Article
  6. Review
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  8. Review
  9. Preparing a Dual-SpeciesMolecular pharmaceutics · 2025
    Article
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  11. Review
  12. Article
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  16. Review
  17. Article
  18. Review
  19. Determination of the Course of Cyan Fluorescence ofDiagnostics (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

David G ArmstrongDepartment of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-1887-9175
Michael E EdmondsDiabetic Foot Clinic, King's College Hospital Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-8931-0069
Thomas E SerenaSerenaGroup® Research Foundation, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1032-3578
King's College Hospital NHS Foundation Trust · GBSerenaGroup Research Institute · USUniversity of Southern California · US

Funding

Improving the science of adherence reinforcement and safe mobility in people with diabetic foot ulcers using smart offloadingR01DK124789 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARMSTRONG, DAVID GEORGE, NAJAFI, BIJAN · 2021 to 2025
$2.0M
NIDDK NIH HHS R01 DK124789
6 · The paper itself

Abstract

Elevated levels of bacteria, including biofilm, increase the risk of chronic wound infection and inhibit healing. Addressing asymptomatic high bacterial loads is challenged by a lack of clinical terminology and diagnostic tools. This post-hoc multicenter clinical trial analysis of 138 diabetic foot ulcers investigates fluorescence (FL)-imaging role in detecting biofilm-encased and planktonic bacteria in wounds at high loads. The sensitivity and specificity of clinical assessment and FL-imaging were compared across bacterial loads of concern (10

Indexed as

Diabetes MellitusDiabetic FootWound InfectionBacteriaBacterial LoadHumansOptical ImagingPoint-of-Care Systemsbacterial loaddiabetic footfluorescence imaginginfectionwound healing

Identifiers

PMID36708275
PMCPMC9885466
OpenAlexW4318339134

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.