ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Incorporation of concussion history as part of the LIfestyle for BRAin Health (LIBRA) modifiable factors risk score and associations with cognition in older former National Football League players.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Demographic and Football-Related Characteristics Associated with Objective Cognitive Performance in Former NFL Players with a Normative Sample Comparison: An NFL-LONG Study.Sports medicine (Auckland, N.Z.) · 2026Article
- The impact of socioeconomic status and lifestyle on cognitive aging and brain health: results from the LIFE-Adult-Study.Alzheimer's research & therapy · 2026Article
- Long-term neurobehavioral and neuroimaging outcomes in athletes with prior concussion(s) and head impact exposure.The Clinical neuropsychologist · 2025Review
- The LIBRA index of modifiable risk factors for mild cognitive impairment and dementia in a late-life population-based cohort study.AJE advances : research in epidemiology · 2025Article
- White Matter Hyperintensities and Microstructural Alterations in Contact Sport Athletes from Adolescence to Early Midlife.Journal of neurotrauma · 2024Article
- ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study.Alzheimer's research & therapy · 2024Article
- Applications and implicit assumptions in dementia risk scores: A scoping review of the LIBRA score.Journal of Alzheimer's disease reportsReview
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveInvestigate associations between the LIfestyle for BRAin Health (LIBRA) risk score with odds of mild cognitive impairment (MCI) diagnosis and cognitive function, incorporating concussion history.
methodsFormer National Football League (NFL) players (N = 1050; mean age = 64.8 ± 9.0-years) completed initial testing for integration of concussion history into LIBRA scores (i.e., modified-LIBRA) and completed the Brief Test of Adult Cognition by Telephone (BTACT). Modified-LIBRA score (including concussion history) associations with odds of MCI and cognitive dysfunction were assessed via logistic and linear regression.
resultsThe highest quartile LIBRA scores were six times more likely to have a diagnosis of MCI compared to the lowest quartile (OR = 6.27[3.61, 10.91], p < 0.001). Modified-LIBRA scores significantly improved model fit for odds of MCI above original LIBRA scores (χ
conclusionsModified-LIBRA score, incorporating concussion history, may help monitoring risk status in former contact sport athletes, by targeting modifiable, lifestyle-related risk factors.
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Registered trials
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