ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023
Age and gender differences in symptom experience and health-related quality of life in kidney transplant recipients: a cross-sectional study.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Computational assessment of memory function in kidney transplant recipients and donors.Communications medicine · 2026Article
- Validation of the modified transplant symptom occurrence and symptom distress scale and exploring symptom burden in Brazilian kidney transplant recipients.Scientific reports · 2026Article
- Patient-reported Outcome Measures in Solid Organ Transplant Recipients: Current use, Challenges, and Recommendations for Future use.Transplantation · 2026Review
- Symptom Burden and Patient-Reported Outcomes in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Studies.Kidney medicine · 2026Article
- Frailty Impact on Kidney Transplantation in Older People.Kidney international reports · 2025Article
- Fatigue across different chronic kidney disease populations: experiences and needs of patients.Clinical kidney journal · 2025Article
- Exploring Early Symptom Experiences and Self-Management Strategies Among Postoperative Kidney Transplant Patients on Symptom Management Theory: A Qualitative Study.Patient preference and adherence · 2025Article
- Time-dependent analysis of erectile dysfunction in kidney transplant recipients: insights from four distinct time periods.BMC infectious diseases · 2024Article
- Self-Management of Kidney Transplant Recipients Research: A Comprehensive Bibliometric Analysis.Journal of multidisciplinary healthcare · 2024Review
- The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis.Psychology research and behavior management · 2024Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundHealth-related quality of life (HRQOL) is an increasingly important patient-reported outcome in kidney transplant recipients (KTRs). This study explored relationships between symptom prevalence and burden with HRQOL, and age and gender differences in symptom experience.
methodsEligible Dutch KTRs transplanted in Leiden University Medical Center were invited for this cross-sectional study. HRQOL, and occurrence and burden of 62 symptoms were measured using validated questionnaires. Univariate and multivariate regression analysis were used for investigating the associations of symptom experience with mental and physical HRQOL, and differences in symptom experience between genders and KTRs of diverse age groups.
resultsA total of 631 KTRs were analyzed; the mean (standard deviation) age was 61.3 (11.3) years, and 62% were male. The median (interquartile range) number of symptoms was 14 (7-22), with a burden of 20 (8-37; range 0-244). Per extra symptom, physical and mental HRQOL decreased [-0.41 (-0.50; -0.31) and -0.51 (-0.59; -0.42), respectively, P < .001]. Most occurring symptoms were bruises, tiredness, lack of energy, urge to urinate at night and dry skin. Sexual problems were considered most burdensome. Female KTRs reported more symptoms than men. Amongst others, younger KTRs experienced more (18-50 > 50-65 ≥65 years) feelings of depression and both female and younger KTRs reported higher symptom prevalence concerning changes in physical appearance.
conclusionKRTs' symptom experience differed depending on gender and age, highlighting the need to develop tailored treatment strategies to reduce symptom experience and subsequently improve HRQOL.
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