Evidence map›Paper›PMID 36707909›Full record

ArticleTrials2023

The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial: rationale and design of an emergency department-based randomized clinical trial of linkage-to-care strategies for hepatitis C.

Sarah E Rowan, Jason Haukoos, Kevin F Kamis, Emily Hopkins, Stephanie Gravitz, Carolynn Lyle, Alia A Al-Tayyib, Edward M Gardner, James W Galbraith, Yu-Hsiang Hsieh and 8 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04026867 (Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04026867 nacompletednot on this map

Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for HCV

TypeinterventionalSponsorDenver Health and Hospital AuthorityRan2019 to 2024Enrolled309ConditionsHepatitis CArmsLinkage Navigation, Clinician Referral
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sarah E RowanDivision of Infectious Diseases, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO, USA.
Jason HaukoosDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of Medicine, 777 Bannock Street, Mail Code 0108, Denver, CO, 80204, USA. jason.haukoos@dhha.org.ORCID http://orcid.org/0000-0001-7784-6811
Kevin F KamisPublic Health Institute at Denver Health, Denver, CO, USA.
Emily HopkinsDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of Medicine, 777 Bannock Street, Mail Code 0108, Denver, CO, 80204, USA.
Stephanie GravitzDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of Medicine, 777 Bannock Street, Mail Code 0108, Denver, CO, 80204, USA.
Carolynn LyleDepartment of Emergency Medicine, Denver Health Medical Center and University of Colorado School of Medicine, 777 Bannock Street, Mail Code 0108, Denver, CO, 80204, USA.
Alia A Al-TayyibPublic Health Institute at Denver Health, Denver, CO, USA.
Edward M GardnerDivision of Infectious Diseases, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO, USA.
James W GalbraithDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Yu-Hsiang HsiehDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA.
Michael S LyonsDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Richard E RothmanDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA.
Douglas A E WhiteDepartment of Emergency Medicine, Highland Hospital, Alameda Health System, Oakland, CA, USA.
Jake R MorganDepartment of Health Law, Policy, and Management, Boston University School of Public Health, Boston, MA, USA.
Benjamin P LinasCenter for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV, Boston, MA, USA.
Allison L SabelDepartment of Patient Safety and Quality, Denver Health, Denver, CO, USA.
David L WylesDivision of Infectious Diseases, Denver Health Medical Center and University of Colorado School of Medicine, Denver, CO, USA.
DETECT Hep C Trials Investigators

Funding

Utilization of health services after engagement with opioid use disorder (OUD) treatment provider by individuals with and without post-traumatic stress disorderP30DA040500 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Yuhua Bao · 2015 to 2026
$20.7M
NIDA NIH HHS P30 DA040500
6 · The paper itself

Abstract

backgroundHepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial.

methodsThe DETECT Hep C Linkage-to-Care Trial will be a single-center prospective comparative effectiveness randomized two-arm parallel-group superiority trial to test the effectiveness of linkage navigation and clinician referral among ED patients identified with untreated HCV with a primary hypothesis that linkage navigation plus clinician referral is superior to clinician referral alone when using treatment initiation as the primary outcome. Participants will be enrolled in the ED at Denver Health Medical Center (Denver, CO), an urban, safety-net hospital with approximately 75,000 annual adult ED visits. This trial was designed to enroll a maximum of 280 HCV RNA-positive participants with one planned interim analysis based on methods by O'Brien and Fleming. This trial will further inform the evaluation of cost effectiveness, disparities, and social determinants of health in linkage-to-care, treatment, and disease progression. DISCUSSION: When complete, the DETECT Hep C Linkage-to-Care Trial will significantly inform how best to perform linkage-to-care among ED patients identified with HCV.

trial registrationClinicalTrials.gov ID: NCT04026867 Original date: July 1, 2019 URL: https://clinicaltrials.gov/ct2/show/NCT04026867.

Indexed as

Hepatitis CMass ScreeningAdultEmergency Service, HospitalEquivalence Trials as TopicHepacivirusHumansProspective StudiesRandomized Controlled Trials as TopicTreatment OutcomeClinical trialComparative effectivenessEmergency departmentHCVHepatitis CImplementationLinkage-to-careMethodsNavigationRandomized trial

Identifiers

PMID36707909
PMCPMC9880363

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.