Evidence map›Paper›PMID 36707777›Full record

ArticleBMC anesthesiology2023

Application of opioid-free general anesthesia for gynecological laparoscopic surgery under ERAS protocol: a non-inferiority randomized controlled trial.

Liang Chen, Wensheng He, Xue Liu, Fahui Lv, Yuanhai Li

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06566482 (Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia for Postoperative Sleep Promotion in Patients at High-risk of Obstructive Sleep Apnea), which is not on this map. Cited by 51 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 9 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06566482 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia for Postoperative Sleep Promotion in Patients at High-risk of Obstructive Sleep Apnea: A Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2024 to 2025Enrolled100ConditionsObstructive Sleep Apnea, Surgery, Dexmedetomidine, EsketamineArmsDexmedetomidine-esketamine combination, Placebo
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 9 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Liang ChenDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Wensheng HeDepartment of Anesthesiology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, People's Republic of China.
Xue LiuDepartment of Anesthesiology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, People's Republic of China.
Fahui LvDepartment of Obstetrics and Gynaecology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, People's Republic of China.
Yuanhai LiDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China. liyuanhai-1@163.com.
Anhui Medical University · CNFirst Affiliated Hospital of Anhui Medical University · CNSecond Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnhanced recovery after surgery (ERAS) is now widely used in various surgical fields including gynecological laparoscopic surgery, but the advantages of opioid-free anesthesia (OFA) in gynecological laparoscopic surgery under ERAS protocol are inexact.

aimsThis study aims to assess the effectiveness and feasibility of OFA technique versus traditional opioid-based anesthesia (OA) technique in gynecological laparoscopic surgery under ERAS.

methodsAdult female patients aged 18 ~ 65 years old undergoing gynecological laparoscopic surgery were randomly divided into OFA group (Group OFA, n = 39) with esketamine and dexmedetomidine or OA group (Group OA, n = 38) with sufentanil and remifentanil. All patients adopted ERAS protocol. The primary outcome was the area under the curve (AUC) of Visual Analogue Scale (VAS) scores (AUC

resultsAUC

conclusionIn gynecological laparoscopic surgery under ERAS protocol, OFA technique is non-inferior to OA technique in analgesic effect and intraoperative anesthesia stability. Although awakening and orientation recovery times were prolonged compared to OA, OFA had lower incidence of PONV and improved postoperative sleep quality.

trial registrationChiCTR2100052761, 05/11/2021.

Indexed as

Enhanced Recovery After SurgeryLaparoscopyAdolescentAdultAgedAnalgesics, OpioidAnesthesia, GeneralEquivalence Trials as TopicFemaleHumansMiddle AgedPostoperative Nausea and VomitingPostoperative PainRandomized Controlled Trials as TopicYoung AdultAnalgesics, OpioidAnalgesiaERASGynecological Laparoscopic surgeryNon-inferiorityOpioid-free anesthesia

Identifiers

PMID36707777
PMCPMC9881250
OpenAlexW4318316266

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.