Evidence map›Paper›PMID 36707725›Full record

ReviewNature reviews. Microbiology2023

Staphylococcus aureus host interactions and adaptation.

Benjamin P Howden, Stefano G Giulieri, Tania Wong Fok Lung, Sarah L Baines, Liam K Sharkey, Jean Y H Lee, Abderrahman Hachani, Ian R Monk, Timothy P Stinear

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 377 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
377citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

377 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The evolving landscape ofFrontiers in immunology · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. An underlying mechanism of bovine mastitis: PGEThe veterinary quarterly · 2026
    Article
  5. Article
  6. Emerging microbes & infections · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Genetic architecture and functional dynamics of integrons in Staphylococcus aureus resistance.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Review
  17. Article
  18. Genetic architecture and functional dynamics of integrons in Staphylococcus aureus resistance.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Review
  19. Article
  20. Article

317 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin P HowdenCentre for Pathogen Genomics, The University of Melbourne, Melbourne, Victoria, Australia. bhowden@unimelb.edu.au.ORCID 0000-0003-0237-1473
Stefano G GiulieriDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-5366-1943
Tania Wong Fok LungDepartment of Paediatrics, Columbia University, New York, NY, USA.ORCID 0000-0002-9318-9572
Sarah L BainesDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-0557-0518
Liam K SharkeyDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-9324-8678
Jean Y H LeeDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-5751-8503
Abderrahman HachaniDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-8032-2154
Ian R MonkDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-6982-8074
Timothy P StinearCentre for Pathogen Genomics, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-0150-123X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined by the interplay between S. aureus and host. This interplay is multidimensional and evolving, exemplified by the spread of S. aureus between humans and other animal reservoirs and the lack of success in vaccine development. In this Review, we examine recent advances in understanding the S. aureus-host interactions that lead to infections. We revisit the primary role of neutrophils in controlling infection, summarizing the discovery of new immune evasion molecules and the discovery of new functions ascribed to well-known virulence factors. We explore the intriguing intersection of bacterial and host metabolism, where crosstalk in both directions can influence immune responses and infection outcomes. This Review also assesses the surprising genomic plasticity of S. aureus, its dualism as a multi-mammalian species commensal and opportunistic pathogen and our developing understanding of the roles of other bacteria in shaping S. aureus colonization.

Indexed as

Staphylococcal InfectionsStaphylococcus aureusAdaptation, PhysiologicalAnimalsHost-Pathogen InteractionsHumansImmune EvasionMammalsVirulence FactorsVirulence Factors

Identifiers

PMID36707725
PMCPMC9882747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.