ArticlePediatric research2023
Post-operative dysnatremia is associated with adverse early outcomes after surgery for congenital heart disease.
Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Incidence, Predictors, and Outcomes of Early Postoperative Dysnatremia After Pediatric Neurosurgery: A Prospective Observational Study.Paediatric anaesthesia · 2026Observational
- Intraoperative sodium range affects white matter microstructure in neonatal congenital heart disease.International journal of cardiology. Congenital heart disease · 2026Article
- Fluid restriction after pediatric cardiac surgery is independently associated With shorter mechanical ventilation: a retrospective cohort study With adjustment for cardiopulmonary bypass time.Frontiers in pediatrics · 2026Article
- Determination of insensible water loss and sodium accumulation behavior from the Medtronic Nautilus Extracorporeal Membrane Oxygenation (ECMO) oxygenator: An in vitro study.The journal of extra-corporeal technology · 2025Article
- Impact of acute kidney injury and dysnatremia on length of stay in infants after cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2025Article
- Postoperative hypernatremia is associated with worse brain injuries on EEG and MRI following pediatric cardiac surgery.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDysnatremia is a common disorder in critically ill surgical children. The study's aim is to determine the prevalence of dysnatremia and its association with outcomes after surgery for congenital heart disease (CHD).
methodsThis is a single-center retrospective cohort study of children <18 years of age undergoing surgery for CHD between January 2012 and December 2014. Multivariable logistic regression analysis was used to evaluate the relationship between dysnatremia and outcomes during the perioperative period. A total of 1345 encounters met the inclusion criteria.
resultsThe prevalence of pre- and post-operative dysnatremia were 10.2% and 47.1%, respectively. Hyponatremia occurred in 19.1%, hypernatremia in 25.6%. Hypernatremia at 24, 48, and 72 h post-operative was associated with increased hospital mortality (odds ratios (OR) [95% confidence intervals (CI)] 3.08 [1.16-8.17], p = 0.024; 4.35 [1.58-12], p = 0.0045; 4.14 [1.32-12.97], p = 0.0148, respectively. Hypernatremia was associated with adverse neurological events 3.39 [1.12-10.23], p = 0.0302 at 48 h post-operative. Hyponatremia was not associated with any adverse outcome in our secondary analysis.
conclusionsPost-operative dysnatremia is a common finding in this heterogeneous cohort of pediatric cardiac-surgical patients. Hypernatremia was more prevalent than hyponatremia and was associated with adverse early post-operative outcomes. IMPACT: Our study has shown that dysnatremia was highly prevalent in children after congenital heart surgery with hypernatremia associated with adverse outcomes including mortality. It is important to understand fluid and sodium regulation in the post-operative period in children with congenital heart disease to better address fluid overload and associated electrolyte imbalances and acute kidney injury. While clinicians are generally very aware of the importance of hyponatremia in critically ill children, similar attention should be given to hypernatremia in this population.
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