Evidence map›Paper›PMID 36707517›Full record

ArticleNature communications2023

Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose.

Zhen Qiao, Julia Sidorenko, Joana A Revez, Angli Xue, Xueling Lu, Katri Pärna, Harold Snieder, Lifelines Cohort Study, Peter M Visscher, Naomi R Wray and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Zhen QiaoGarvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Julia SidorenkoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0003-1494-6772
Joana A RevezInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0003-3204-5396
Angli XueGarvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Xueling LuDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Katri PärnaDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0003-1949-2298
Lifelines Cohort Study
Peter M VisscherInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0002-2143-8760
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0001-7421-3357
Loic YengoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. l.yengodimbou@uq.edu.au.ORCID 0000-0002-4272-9305
The University of Queensland · AUUniversity Medical Center Groningen · NLGarvan Institute of Medical Research · AU

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

The genetic regulation of post-prandial glucose levels is poorly understood. Here, we characterise the genetic architecture of blood glucose variably measured within 0 and 24 h of fasting in 368,000 European ancestry participants of the UK Biobank. We found a near-linear increase in the heritability of non-fasting glucose levels over time, which plateaus to its fasting state value after 5 h post meal (h

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2FastingGenome-Wide Association StudyGlucoseHumansPolymorphism, Single NucleotideBlood GlucoseGlucose

Identifiers

PMID36707517
PMCPMC9883484
OpenAlexW4318309563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.