ReviewNPJ microgravity2023
Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration.
Review in NPJ microgravity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Limited musculoskeletal benefits of artificial gravity combined with cycling during bed rest: Results from the BRACE study.Experimental physiology · 2026Trial
- The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.Experimental physiology · 2026Review
- Comparison of musculoskeletal responses and its variability after long-term spaceflight and prolonged bed rest conditions.NPJ microgravity · 2026Article
- Simulated Microgravity-Induced Changes in SUMOylation and Protein Expression inInternational journal of molecular sciences · 2025Article
- Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.NPJ microgravity · 2025Review
- Recovery of bone microarchitecture and density four years after spaceflight: two case studies.NPJ microgravity · 2025Article
- Resistance and Aerobic Preconditioning Delays Unloading-Induced Multisystemic Physiological Changes: The NEBULA Project.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Long non-coding RNAs Kcnq1ot1 and Lncpint are involved in skeletal muscle atrophy induced by the space exposome.The Journal of physiology · 2025Article
- Plyometric training increases thickness and volume of knee articular cartilage in mice.NPJ microgravity · 2025Article
- Variability in individual musculoskeletal response is not increased by countermeasures during bed rest.Frontiers in physiology · 2025Article
- Articular cartilage loss is an unmitigated risk of human spaceflight.NPJ microgravity · 2024Review
- Exploring New Horizons: Advancements in Cartilage Tissue Engineering Under Space Microgravity.Cureus · 2024Review
- Microgravity triggers ferroptosis and accelerates senescence in the MG-63 cell model of osteoblastic cells.NPJ microgravity · 2023Article
- Spaceflight Induces Strength Decline inCells · 2023Article
- Cerebral Circulation and Brain Temperature during an Ultra-Short Session of Dry Immersion in Young Subjects.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper "Human Physiology - Musculoskeletal system", this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.