Evidence map›Paper›PMID 36707505›Full record

ReviewTranslational psychiatry2023

Psychological and biological mechanisms linking trauma with cardiovascular disease risk.

Jennifer A Sumner, Shiloh Cleveland, Tiffany Chen, Jaimie L Gradus

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

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  8. Cardiac event-induced PTSD symptoms and continuous heart rate in coronary artery disease patients.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jennifer A SumnerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. jsumner@psych.ucla.edu.ORCID 0000-0002-0217-7171
Shiloh ClevelandDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Tiffany ChenDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Jaimie L GradusDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
University of California, Los Angeles · USBoston University · US

Funding

Identifying Early Intervention Targets for Reducing Cardiovascular Risk in Posttraumatic StressR01HL139614 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMNER, JENNIFER A · 2018 to 2022
$3.9M
Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal InvestigationR01HL160850 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRADUS, JAIMIE L., SUMNER, JENNIFER A · 2022 to 2025
$2.6M
NHLBI NIH HHS R01 HL139614NHLBI NIH HHS R01 HL160850
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and experiences of psychological trauma have been associated with subsequent CVD onset. Identifying key pathways connecting trauma with CVD has the potential to inform more targeted screening and intervention efforts to offset elevated cardiovascular risk. In this narrative review, we summarize the evidence for key psychological and biological mechanisms linking experiences of trauma with CVD risk. Additionally, we describe various methodologies for measuring these mechanisms in an effort to inform future research related to potential pathways. With regard to mechanisms involving posttraumatic psychopathology, the vast majority of research on psychological distress after trauma and CVD has focused on posttraumatic stress disorder (PTSD), even though posttraumatic psychopathology can manifest in other ways as well. Substantial evidence suggests that PTSD predicts the onset of a range of cardiovascular outcomes in trauma-exposed men and women, yet more research is needed to better understand posttraumatic psychopathology more comprehensively and how it may relate to CVD. Further, dysregulation of numerous biological systems may occur after trauma and in the presence of posttraumatic psychopathology; these processes of immune system dysregulation and elevated inflammation, oxidative stress, mitochondrial dysfunction, renin-angiotensin system dysregulation, and accelerated biological aging may all contribute to subsequent cardiovascular risk, although more research on these pathways in the context of traumatic stress is needed. Given that many of these mechanisms are closely intertwined, future research using a systems biology approach may prove fruitful for elucidating how processes unfold to contribute to CVD after trauma.

Indexed as

Cardiovascular DiseasesStress Disorders, Post-TraumaticFemaleHumansMale

Identifiers

PMID36707505
PMCPMC9883529
OpenAlexW4318218766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.