Evidence map›Paper›PMID 36707500›Full record

ArticleMolecular pharmaceutics2023

Controlled Delivery of Vancomycin from Collagen-tethered Peptide Vehicles for the Treatment of Wound Infections.

Jeongmin Hwang, Haofu Huang, Millicent O Sullivan, Kristi L Kiick

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

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  8. Synthesis of aACS applied bio materials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeongmin HwangDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware19713, United States.ORCID 0000-0001-8799-3209
Haofu HuangDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware19716, United States.
Millicent O SullivanDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware19713, United States.
Kristi L KiickDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware19713, United States.ORCID 0000-0001-8587-0301
University of Delaware · US

Funding

Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
COATs: Collagen-mimetic peptide and therapeutic gene-modified collagens for cell-mediated healing of diabetic foot ulcersR01DK130662 · NIDDK · UNIVERSITY OF DELAWARE · PI KIICK, KRISTI L, MARGOLIS, DAVID JOEL · 2021 to 2025
$2.6M
Collagen turnover-stimulated gene delivery to enhance chronic wound repairR01AR067247 · NIAMS · UNIVERSITY OF DELAWARE · PI KIICK, KRISTI L, MARGOLIS, DAVID · 2016 to 2019
$1.4M
NIAMS NIH HHS R01 AR067247NIDDK NIH HHS R01 DK130662NIGMS NIH HHS P30 GM110758
6 · The paper itself

Abstract

Despite the great promise of antibiotic therapy in wound infections, antibiotic resistance stemming from frequent dosing diminishes drug efficacy and contributes to recurrent infection. To identify improvements in antibiotic therapies, new antibiotic delivery systems that maximize pharmacological activity and minimize side effects are needed. In this study, we developed elastin-like peptide and collagen-like peptide nanovesicles (ECnVs) tethered to collagen-containing matrices to control vancomycin delivery and provide extended antibacterial effects against methicillin-resistant

Indexed as

Methicillin-Resistant Staphylococcus aureusWound InfectionAnti-Bacterial AgentsCollagenHumansLiposomesMicrobial Sensitivity TestsVancomycinAnti-Bacterial AgentsCollagenLiposomesVancomycincollagencollagen-like peptide (CLP)elastin-like peptide (ELP)hydrogelmethicillin-resistant Staphylococcus aureus (MRSA)vancomycinwound dressing

Identifiers

PMID36707500
PMCPMC10197141
OpenAlexW4318305547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.