Evidence map›Paper›PMID 36707113›Full record

ArticleBMJ open2023

Early urine output monitoring in very preterm infants to predict in-hospital neonatal outcomes: a bicentric retrospective cohort study.

Aurélie De Mul, Alice Heneau, Valérie Biran, Alexandra Wilhelm-Bals, Paloma Parvex, Antoine Poncet, Marie Saint-Faust, Olivier Baud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Aurélie De MulDépartement de la Femme, de l'Enfant et de l'Adolescent, Service des soins intensifs pédiatriques et néonatals, Hôpitaux Universitaires de Genève, Geneve, Switzerland.ORCID 0000-0002-7658-3068
Alice HeneauDépartement de Pédiatrie, Service de réanimation et médecine néonatales, Hopital Universitaire Robert Debré, Paris, France.
Valérie BiranDépartement de Pédiatrie, Service de réanimation et médecine néonatales, Hopital Universitaire Robert Debré, Paris, France.
Alexandra Wilhelm-BalsDépartement de la Femme, de l'Enfant et de l'Adolescent, Unité de néprologie pédiatrique, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Paloma ParvexDépartement de la Femme, de l'Enfant et de l'Adolescent, Unité de néprologie pédiatrique, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Antoine PoncetCentre de Recherche Clinique, Division d'épidémiologie clinique, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Marie Saint-Faust *Département de la Femme, de l'Enfant et de l'Adolescent, Service des soins intensifs pédiatriques et néonatals, Hôpitaux Universitaires de Genève, Geneve, Switzerland.
Olivier Baud *Département de la Femme, de l'Enfant et de l'Adolescent, Service des soins intensifs pédiatriques et néonatals, Hôpitaux Universitaires de Genève, Geneve, Switzerland olivier.baud@hcuge.ch.ORCID 0000-0001-5021-0522
Inserm · FRHirslanden Clinique La Colline · CHHôpital Robert-Debré · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether urine output (UO), rarely assessed in the literature, is associated with relevant neonatal outcomes in very preterm infants, and which UO threshold may be the most clinically relevant.

designRetrospective cohort study.

settingTwo Level IV neonatal intensive care units. PATIENTS: Very preterm infants born between 24

main outcome measuresComposite outcome defined as death before discharge, or moderate to severe bronchopulmonary dysplasia, or severe brain lesions. The association between this outcome and UO was studied using several UO thresholds.

resultsAmong 532 infants studied, UO <1.0 mL/kg/hour for at least 24 consecutive hours was measured in 55/532 (10%) infants and the primary outcome was recorded in 25 patients. The association between a UO threshold <1.0 mL/kg/hour and the primary outcome was found marginally significant (crude OR 1.80, 95% CI 1.02 to 3.16, p=0.04). The primary outcome was recorded in 112/242 (46%) patients with a UO <2.0 mL/kg/hour and only 64/290 (22%) patients with a UO ≥2.0 mL/kg/hour (p<0.001). This UO threshold was found significantly associated with the primary outcome (crude OR 3.1, 95% CI 2.1 to 4.7, p<0.001), an association confirmed using a multivariate logistic regression model including baseline covariates (adjusted OR 3.7, 95% CI 2.2 to 6.4, p<0.001).

conclusionA UO <2 mL/kg/hour over 24 hours between postnatal day 1 and day 7 strongly predicts neonatal mortality or severe morbidities in very preterm infants.

Indexed as

Bronchopulmonary DysplasiaInfant, Premature, DiseasesFemaleHumansInfantInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightRetrospective StudiesAcute renal failureKidney & urinary tract disordersNeonatal intensive & critical careNEONATOLOGYNephrology

Identifiers

PMID36707113
PMCPMC9884922
OpenAlexW4318390876

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.