Evidence map›Paper›PMID 36706929›Full record

ArticleNeurobiology of disease2023

Evoked resonant neural activity in subthalamic local field potentials reflects basal ganglia network dynamics.

Christoph Wiest, Shenghong He, Benoit Duchet, Alek Pogosyan, Moaad Benjaber, Timothy Denison, Harutomo Hasegawa, Keyoumars Ashkan, Fahd Baig, Ilaria Bertaina and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Pallidal Evoked Resonant Neural Activity as a Candidate Biomarker for Deep Brain Stimulation in Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Paired Deep Brain Stimuli Elicit Short-Term Facilitation in Globus Pallidus Interna and Subthalamic Nucleus.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. State identification of Parkinson's disease based on transfer learning.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christoph WiestMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Shenghong HeMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Benoit DuchetMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Alek PogosyanMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Moaad BenjaberMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Timothy DenisonMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Harutomo HasegawaDepartment of Neurosurgery, King's College Hospital, Denmark Hill, London, UK.
Keyoumars AshkanDepartment of Neurosurgery, King's College Hospital, Denmark Hill, London, UK.
Fahd BaigMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK.
Ilaria BertainaNeurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK; Neurology Department, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Francesca MorganteNeurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK.
Erlick A PereiraNeurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK.
Flavie TorrecillosMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Huiling TanMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: huiling.tan@ndcn.ox.ac.uk.

Funding

Department of HealthMedical Research Council MR/P012272/1Medical Research Council MR/V00655X/1
6 · The paper itself

Abstract

Evoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation (DBS) and was recently suggested as a marker of lead placement and contact selection in Parkinson's disease. Yet, its underlying mechanisms and how it is modulated by stimulation parameters are unclear. Here, we recorded local field potentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. First, we show that ERNA in the time series waveform and spectrogram likely represent the same activity, which was contested before. Second, our results show that the ERNA has fast and slow dynamics during stimulation, consistent with the synaptic failure hypothesis. Third, we show that ERNA parameters are modulated by different DBS frequencies, intensities, medication states and stimulation modes (continuous DBS vs. adaptive DBS). These results suggest the ERNA might prove useful as a predictor of the best DBS frequency and lowest effective intensity in addition to contact selection. Changes with levodopa and DBS mode suggest that the ERNA may indicate the state of the cortico-basal ganglia circuit making it a putative biomarker to track clinical state in adaptive DBS.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusBasal GangliaEvoked PotentialsHumansLevodopaLevodopaAdaptive DBSDeep brain stimulationEvoked resonant neural activityLocal field potentialsParkinson's diseaseSubthalamic nucleus

Identifiers

PMID36706929
PMCPMC7614125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.