ArticleNeuron2023
Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 70 citations in OpenAlex.
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- Reconciling time and prediction error theories of associative learning.Nature communications · 2025Article
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- Psychedelics Reverse the Polarity of Long-Term Synaptic Plasticity in Cortical-Projecting Claustrum Neurons.eNeuro · 2025Article
- Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain.Nature communications · 2025Article
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- Compromising Tyrosine Hydroxylase Function Extends and Blunts the Temporal Profile of Reinforcement by Dopamine Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release.Nature communications · 2025Article
- Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning.Science advances · 2024Article
- Experience-dependent serotonergic signaling in glia regulates targeted synapse elimination.PLoS biology · 2024Article
- Systemic Modulators: Potential Mechanism for the 5-HT System to Mediate Exercise Amelioration in Alzheimer's Disease.Aging and disease · 2024Review
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Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
The coincidence between conditioned stimulus (CS) and unconditioned stimulus (US) is essential for associative learning; however, the mechanism regulating the duration of this temporal window remains unclear. Here, we found that serotonin (5-HT) bi-directionally regulates the coincidence time window of olfactory learning in Drosophila and affects synaptic plasticity of Kenyon cells (KCs) in the mushroom body (MB). Utilizing GPCR-activation-based (GRAB) neurotransmitter sensors, we found that KC-released acetylcholine (ACh) activates a serotonergic dorsal paired medial (DPM) neuron, which in turn provides inhibitory feedback to KCs. Physiological stimuli induce spatially heterogeneous 5-HT signals, which proportionally gate the intrinsic coincidence time windows of different MB compartments. Artificially reducing or increasing the DPM neuron-released 5-HT shortens or prolongs the coincidence window, respectively. In a sequential trace conditioning paradigm, this serotonergic neuromodulation helps to bridge the CS-US temporal gap. Altogether, we report a model circuitry for perceiving the temporal coincidence and determining the causal relationship between environmental events.
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Registered trials
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