Evidence map›Paper›PMID 36706636›Full record

ArticleMedical image analysis2023

Computing personalized brain functional networks from fMRI using self-supervised deep learning.

Hongming Li, Dhivya Srinivasan, Chuanjun Zhuo, Zaixu Cui, Raquel E Gur, Ruben C Gur, Desmond J Oathes, Christos Davatzikos, Theodore D Satterthwaite, Yong Fan

Abstract read
In one paragraph

Article in Medical image analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Review
  10. SpaRG: Sparsely Reconstructed Graphs for Generalizable fMRI Analysis.Machine learning in clinical neuroimaging : 7th international workshop, MLCN 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, proceedings. MLCN (Workshop) (7th : 2024 : Marrakesh, Morocco) · 2025
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  12. bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongming LiCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dhivya SrinivasanCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Chuanjun ZhuoKey Laboratory of Brain Circuit Real Time Tracing (BCRTT-Lab), Tianjin University Affiliated Tianjin Fourth Center Hospital; Department of Psychiatry, Tianjin Medical University, Tianjin, China.
Zaixu CuiChinese Institute for Brain Research, Beijing, 102206, China.
Raquel E GurCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ruben C GurCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Desmond J OathesCenter for Neuromodulation in Depression and Stress, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christos DavatzikosCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Theodore D SatterthwaiteDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yong FanCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
Individualized Closed Loop TMS for Working Memory EnhancementR01MH120811 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG, OATHES, DESMOND · 2019 to 2023
$3.5M
Fast and robust deep learning tools for analysis of neuroimaging data of Alzheimer's diseaseR01AG066650 · NIA · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG · 2021 to 2025
$3.4M
Longitudinal multi-modal neuroimaging of irritability in youthR01MH107703 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SATTERTHWAITE, THEODORE · 2015 to 2018
$2.6M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
NIA NIH HHS R01 AG066650NIBIB NIH HHS R01 EB022573NIH HHS S10 OD023495NIMH NIH HHS R01 MH107703NIMH NIH HHS R01 MH120811
6 · The paper itself

Abstract

A novel self-supervised deep learning (DL) method is developed to compute personalized brain functional networks (FNs) for characterizing brain functional neuroanatomy based on functional MRI (fMRI). Specifically, a DL model of convolutional neural networks with an encoder-decoder architecture is developed to compute personalized FNs directly from fMRI data. The DL model is trained to optimize functional homogeneity of personalized FNs without utilizing any external supervision in an end-to-end fashion. We demonstrate that a DL model trained on fMRI scans from the Human Connectome Project can identify personalized FNs and generalizes well across four different datasets. We further demonstrate that the identified personalized FNs are informative for predicting individual differences in behavior, brain development, and schizophrenia status. Taken together, the self-supervised DL allows for rapid, generalizable computation of personalized FNs.

Indexed as

ConnectomeDeep LearningBrainHumansMagnetic Resonance ImagingNeural Networks, ComputerBrain functional networksPersonalizedSelf-supervised learning

Identifiers

PMID36706636
PMCPMC10103143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.