Evidence map›Paper›PMID 36706353›Full record

ArticleJournal of the American Chemical Society2023

Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.

Benjamin Weissman, Şölen Ekesan, Hsuan-Chun Lin, Shahbaz Gardezi, Nan-Sheng Li, Timothy J Giese, Erika McCarthy, Michael E Harris, Darrin M York, Joseph A Piccirilli

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. MgJournal of the American Chemical Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Transition State Analysis of SAMHD1 from PrimaryJournal of the American Chemical Society · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Benjamin WeissmanDepartment of Chemistry and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0003-0804-0464
Şölen EkesanLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-5598-5754
Hsuan-Chun LinDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Shahbaz GardeziDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Nan-Sheng LiDepartment of Chemistry and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-1185-3688
Timothy J GieseLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-0653-9168
Erika McCarthyLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0001-8089-0207
Michael E HarrisDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0001-8977-4392
Darrin M YorkLaboratory for Biomolecular Simulation Research, Institute for Quantitative Biomedicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-9193-7055
Joseph A PiccirilliDepartment of Chemistry and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-0541-6270
Rutgers, The State University of New Jersey · USUniversity of Chicago · USUniversity of Florida · US

Funding

Multi-Scale Quantum Models for Ribozyme CatalysisR01GM062248 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Darrin M York · 2001 to 2026
$7.1M
Specificity in Substrate Recognition and Catalysis by RNA Processing EnzymesR35GM127100 · NIGMS · UNIVERSITY OF FLORIDA · PI HARRIS, MICHAEL E. · 2018 to 2022
$1.6M
The VS Ribozyme: Catalytic Mechanism, Transition State Structure, and EvolutionR01GM131568 · NIGMS · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM062248NIGMS NIH HHS R01 GM131568NIGMS NIH HHS R35 GM127100
6 · The paper itself

Abstract

Ribonucleases and small nucleolytic ribozymes are both able to catalyze RNA strand cleavage through 2'-

Indexed as

RNA, CatalyticCatalysisCatalytic DomainHepatitis Delta VirusKineticsNucleic Acid ConformationRNARNARNA, Catalytic

Identifiers

PMID36706353
PMCPMC10112047
OpenAlexW4318262950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.