Evidence map›Paper›PMID 36705889›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2023

circRNA_0067717 promotes paclitaxel resistance in nasopharyngeal carcinoma by acting as a scaffold for TRIM41 and p53.

Yaxin Cheng, Yuxing Zhu, Mengqing Xiao, Yeyu Zhang, Zhanwang Wang, Haotian Chen, Ke Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yaxin ChengDepartment of Oncology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, China.
Yuxing ZhuDepartment of Oncology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, China.
Mengqing XiaoDepartment of Oncology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, China.
Yeyu ZhangDepartment of Oncology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, China.
Zhanwang WangDepartment of Oncology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, China.
Haotian ChenDepartment of Oncology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, China.
Ke CaoDepartment of Oncology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, China. csucaoke@163.com.
Central South University · CNThird Xiangya Hospital · CN

Funding

Funds for International Cooperation and Exchange of the National Natural Science Foundation of China GZ1699Hunan Provincial Innovation Foundation for Postgraduate CX20190253key research and development projects in Hunan Province 2022SK2022Scientific research project of Hunan Provincial Health Commission 202209034683the Hunan Province Science and Technology Talent Promotion Project 2019TJ-Q10the National Natural Science Foundation of China 81874137the science and technology innovation Program of Hunan Province 2020RC4011the Wisdom Accumulation and Talent Cultivation Project of the Third xiangya hosipital of Central South University BJ202001
6 · The paper itself

Abstract

purposeCircular RNAs (circRNAs) play important roles in tumour progression. This study aimed to explore the mechanism of hsa_circ_0067717 (termed circRNA_0067717) promoting paclitaxel resistance in nasopharyngeal carcinoma (NPC).

methodsWe assayed CNE-1 and HNE-2 parental cell lines and the corresponding paclitaxel-resistant NPC cell lines using circRNA microarrays. RNA pull-down assay, RNA immunoprecipitation, and RNA fluorescence in situ hybridization were used to identify the molecular mechanisms.

resultsHere, we confirm that circRNA_0067717 is significantly upregulated in NPC paclitaxel-resistant cells and is associated with paclitaxel resistance in NPC. Mechanistically, circRNA_0067717 functions as a scaffold for TRIM41 protein (a ubiquitin E3 ligase) and p53 protein. In nasopharyngeal carcinoma paclitaxel-resistant cells, the highly expressed circRNA_0067717 can bind to more TRIM41 and p53 protein, promoting TRIM41-induced p53 ubiquitination and degradation, resulting in a decrease in p53 protein level. Moreover, the 1-176 nt area of circRNA_0067717 and the 301-425 nt region of circRNA_0067717 are the binding sites for p53 and TRIM41, respectively. The resistance of NPC cells to paclitaxel can be reduced by blocking these binding regions of circRNA_0067717.

conclusionWe demonstrate that circRNA_0067717 acts as a scaffold for TRIM41 and p53, enhancing paclitaxel chemoresistance in NPC by promoting TRIM41-induced p53 degradation via ubiquitination.

Indexed as

MicroRNAsNasopharyngeal NeoplasmsCell Line, TumorCell ProliferationHumansIn Situ Hybridization, FluorescenceNasopharyngeal CarcinomaPaclitaxelRNA, CircularTumor Suppressor Protein p53Ubiquitin-Protein LigasesMicroRNAsPaclitaxelRNA, CircularTRIM41 protein, humanTumor Suppressor Protein p53Ubiquitin-Protein LigasesChemotherapy resistancecircRNA_0067717Nasopharyngeal carcinomap53TRIM41

Identifiers

PMID36705889
PMCPMC12974661
OpenAlexW4318245572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.