Evidence map›Paper›PMID 36705784›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Occurrence of secondary insults during endovascular treatment of acute ischemic stroke and impact on outcome: the SIR-STROKE prospective observational study.

Anna Teresa Mazzeo, Simone Cappio Borlino, Stefano Malerba, Giulia Catozzi, Claudia Filippini, Vincenzo Francesco Tripodi, Andrea Naldi, Paolo Cerrato, Mauro Bergui, Luciana Mascia

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Anna Teresa MazzeoAnesthesia and Intensive Care, Department of Surgical Sciences, University of Turin, Turin, Italy. annateresamazzeo@unime.it.ORCID http://orcid.org/0000-0002-8454-7243
Simone Cappio BorlinoAnesthesia and Intensive Care, Department of Surgical Sciences, University of Turin, Turin, Italy.
Stefano MalerbaAnesthesia and Intensive Care, Department of Surgical Sciences, University of Turin, Turin, Italy.
Giulia CatozziAnesthesia and Intensive Care, Department of Surgical Sciences, University of Turin, Turin, Italy.
Claudia FilippiniAnesthesia and Intensive Care, Department of Surgical Sciences, University of Turin, Turin, Italy.
Vincenzo Francesco TripodiAnesthesia and Intensive Care, Department of Human Pathology, University of Messina, Via Consolare Valeria, Messina, Italy.ORCID http://orcid.org/0000-0002-1661-6171
Andrea NaldiDepartment of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy.
Paolo CerratoDepartment of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy.
Mauro BerguiDepartment of Neuroradiology, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0002-5336-695X
Luciana MasciaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-3286-0588
University of Turin · ITUniversity of Messina · ITUniversity of Milan · ITUniversity of Bologna · IT

Funding

Compagnia di San Paolo S1618_L2_MAZA_01
6 · The paper itself

Abstract

backgroundNeurological outcome after endovascular treatment (EVT) of acute ischemic stroke (AIS) may depend on both patient-specific and procedural factors. We hypothesized that altered systemic homeostasis might be frequent and affect outcome in these patients. The aim of this study was to analyze secondary insults during EVT of AIS and its association with outcome and anesthesiologic regimen.

methodsThis was a single-center prospective observational study on patients undergoing EVT for AIS under local anesthesia (LA), conscious sedation (CS), or general anesthesia (GA). Altered systemic parameters were recorded and quantified as secondary insults. The primary endpoint was to evaluate number, duration, and severity of secondary insults during EVT. Secondary endpoints were to analyze association of insults with modified Rankin Scale at 90 days and anesthesiologic regimen. RESULTS AND

conclusionsOne hundred twenty patients were enrolled. Overall, 78% of patients experienced at least one episode of hypotension, 21% hypertension, 54% hypoxemia, 16% bradycardia, and 13% tachycardia. In patients monitored with capnometry, 70% experienced hypocapnia and 21% hypercapnia. LA was selected in 24 patients, CS in 84, and GA in 12. Hypotension insult was more frequent during GA than LA and CS (p = 0.0307), but intraprocedural blood pressure variation was higher during CS (p = 0.0357). Hypoxemia was more frequent during CS (p = 0.0087). Proportion of hypotension duration was higher in unfavorable outcome but secondary insults did not remain in the final model of multivariable analysis. Secondary insults occurred frequently during EVT for AIS but the main predictors of outcome were age, NIHSS at admission, and prompt and successful recanalization.

Indexed as

Brain IschemiaEndovascular ProceduresHypotensionIschemic StrokeStrokeAnesthesia, GeneralHumansThrombectomyTreatment OutcomeAcute ischemic strokeAnesthesiaAnterior occlusionEndovascular treatmentPosterior occlusionSecondary insult

Identifiers

PMID36705784
OpenAlexW4318215340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.