Evidence map›Paper›PMID 36705780›Full record

ArticleJournal of gastrointestinal cancer2023

Clinical Significance of Overexpression of Oct4 in Advanced Stage Gallbladder Carcinoma.

Deepika Singh, Dipanjan Biswas, Mallika Tewari, Amrita Ghosh Kar, Mumtaz Ahmad Ansari, Sunita Singh, Gopeshwar Narayan

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Deepika SinghCancer Genetics Laboratory, Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Dipanjan BiswasDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Mallika TewariDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Amrita Ghosh KarDepartment of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Mumtaz Ahmad AnsariDepartment of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Sunita SinghDepartment of Zoology, Banaras Hindu University, Mahila Mahavidyalaya, Varanasi, 221005, India.
Gopeshwar NarayanCancer Genetics Laboratory, Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. gnarayan@bhu.ac.in.
Institute of Medical Sciences · INBanaras Hindu University · INTata Memorial Hospital · INThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOct4 has critical role in maintaining pluripotency, proliferative potential, and self-renewal capacity in embryonic stem and germ cells. Although Oct4 has been shown to be upregulated in many cancers, its clinical significance in gallbladder carcinoma is poorly understood.

methodsWe studied the expression profile of Oct4 in 61 GBC and 30 chronic cholecystitis (as control) using real time RT-PCR, western blotting, and immunohistochemistry. The expression data was correlated with clinico-pathological parameters. The diagnostic utility was assessed through ROC curve, and prognostic value was analyzed by Kaplan-Meier method.

resultsOct4 was significantly upregulated at mRNA as well as protein levels. The higher mRNA expression shows significant association with late stage, late T stage, and higher grade of tumor. A significant positive correlation was also observed with stage, T stage, and tumor grade. Sum score analysis of protein expression shows positive correlation with stage and the presence or absence of gallstone in tumor samples. The ROC curve analysis revealed the moderate diagnostic potential of Oct4. Kaplan-Meier analysis showed that patients having higher expression of Oct4 were having low mean survival compared with the patients with lower Oct4 expression.

conclusionIn conclusion, our data suggests that higher expression of Oct4 may serve as potential biological indicator for tumor aggressiveness and poor prognosis of GBC.

Indexed as

Gallbladder NeoplasmsOctamer Transcription Factor-3Biomarkers, TumorCholecystitisHumansIndiaPrognosisSurvival AnalysisBiomarkers, TumorOctamer Transcription Factor-3POU5F1 protein, humanDiagnostic utilityGallbladder cancerImmunohistochemistryOct4Prognosis

Identifiers

PMID36705780
OpenAlexW4318200311

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.