Evidence map›Paper›PMID 36705732›Full record

ArticleAnalytical and bioanalytical chemistry2023

A highly sensitive LC-MS/MS method for quantitative determination of 7 vitamin D metabolites in mouse brain tissue.

Andrea Joy Stephenson, Benjamin Hunter, Paul Nicholas Shaw, Nur Sofiah Abu Kassim, Robert Trengove, Ryu Takechi, Virginie Lam, John Mamo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Determination of 25-Hydroxyvitamin DBiomedical chromatography : BMC · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Andrea Joy StephensonCurtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
Benjamin HunterCurtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
Paul Nicholas ShawSchool of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia.
Nur Sofiah Abu KassimSchool of Chemistry and Environment, Faculty of Applied Science, University Teknologi MARA, Negeri Sembilan, Cawangan Negeri Sembilan, Kampus Kuala Pilah, Kuala Pilah, Malaysia.
Robert TrengoveCurtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
Ryu TakechiCurtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
Virginie LamCurtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
John MamoCurtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Perth, WA, Australia. J.Mamo@curtin.edu.au.
Curtin University · AUMalaysia Theological Seminary · MYMurdoch University · AUUniversity of Queensland · AU

Funding

National Health and Medical Research Council GNT1122734National Health and Medical Research Council GNT1135590National Health and Medical Research Council GNT2001090
6 · The paper itself

Abstract

Despite its critical role in neurodevelopment and brain function, vitamin D (vit-D) homeostasis, metabolism, and kinetics within the central nervous system remain largely undetermined. Thus, it is of critical importance to establish an accurate, highly sensitive, and reproducible method to quantitate vit-D in brain tissue. Here, we present a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) method and for the first time, demonstrate detection of seven major vit-D metabolites in brain tissues of C57BL/6J wild-type mice, namely 1,25(OH)

Indexed as

MethanolTandem Mass SpectrometryAnimalsBrainChromatography, LiquidFormatesMiceMice, Inbred C57BLVitamin DVitaminsFormatesformic acidMethanolVitamin DVitamins1,25(OH)D24,25(OH)D25(OH)D3-Epi-1,25(OH)DBrainLiquid chromatography tandem mass spectrometryVitamin D

Identifiers

PMID36705732
PMCPMC9928823
OpenAlexW4318218425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.