Evidence map›Paper›PMID 36705703›Full record

ReviewJournal of pediatric gastroenterology and nutrition2023

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts.

Nicholas David Embleton, Sissel Jennifer Moltu, Alexandre Lapillonne, Chris H P van den Akker, Virgilio Carnielli, Christoph Fusch, Konstantinos Gerasimidis, Johannes B van Goudoever, Nadja Haiden, Silvia Iacobelli and 13 more

Registry-linked trialOpen access · greenAbstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Journal of pediatric gastroenterology and nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06199102 (The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.), which is not on this map. Cited by 264 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 13 pooled it
38.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06199102 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. A Randomized Controlled Study.

TypeinterventionalSponsorPrincess Anna Mazowiecka Hospital, Warsaw, PolandRan2024 to 2027Enrolled130ConditionsVitamin D Deficiency, Osteopenia of Prematurity, Nephrolithiasis, Metabolic Bone DiseaseArmscholecalciferol/ Devikap
3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 13 syntheses or guidelines pooled it, 372 citations in OpenAlex.

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  4. Prevention and management of metabolic bone disease of prematurity: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026
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  6. Guideline
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  10. [Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Guideline
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204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 20 institutions in 15 countries.

Nicholas David EmbletonFrom the Newcastle Hospitals NHS Trust and Newcastle University, Newcastle upon Tyne, UK.
Sissel Jennifer Moltuthe Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway.
Alexandre LapillonneAPHP Necker-Enfants Malades Hospital, Paris University, Paris, France.
Chris H P van den Akkerthe Department of Pediatrics - Neonatology, Amsterdam UMC - Emma Children's Hospital, University of Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Virgilio CarnielliPolytechnic University of Marche and Division of Neonatology, Ospedali Riuniti, Ancona, Ancona, Italy.
Christoph Fuschthe Department of Pediatrics, Nuremberg General Hospital, Paracelsus Medical School, Nuremberg, Germany.
Konstantinos Gerasimidisthe Human Nutrition, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
Johannes B van GoudoeverAmsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, Amsterdam, The Netherlands.
Nadja Haidenthe Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Silvia Iacobellithe Réanimation Néonatale et Pédiatrique, Néonatologie - CHU La Réunion, Saint-Pierre, France.
Mark J Johnsonthe Department of Neonatal Medicine, University Hospital Southampton NHS Trust, Southampton, UK.
Sascha Meyerthe Department of General Paediatrics and Neonatology, University Hospital of Saarland, Homburg, Germany.
Walter Mihatschthe Department of Pediatrics, Ulm University, Ulm, Germany.
Miguel Saenz de Pipaonthe Department of Pediatrics-Neonatology, La Paz University Hospital, Autonoma University of Madrid, Madrid, Spain.
Jacques Rigothe Neonatal Unit, University of Liège, CHR Citadelle, Liège, Belgium.
Gitte ZachariassenH.C. Andersen Children's Hospital, Odense University Hospital and University of Southern Denmark, Odense, Denmark.
Jiri Bronskythe Department of Paediatrics, University Hospital Motol, Prague, Czech Republic.
Flavia Indriothe Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Jutta Köglmeierthe Department of Paediatric Gastroenterology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Barbara de Koningthe Paediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Lorenzo Norsathe Paediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIIII, Bergamo, Italy.
Elvira Verducithe Department of Health Sciences, University of Milan, Milan, Italy.
Magnus Domellöfthe Department of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.
Nuremberg Hospital · DEAmsterdam University Medical Centers · NLBaylor College of Medicine · USEmma Kinderziekenhuis · NLErasmus MC - Sophia Children’s Hospital · NLGreat Ormond Street Hospital for Children NHS Foundation Trust · GBImation (United States) · USInstitut Necker Enfants Malades · FRMarche Polytechnic University · ITMedical University of Vienna · ATNIHR Newcastle Biomedical Research Centre · GBOslo University Hospital · NOSaarland University · DEUniversidad Autónoma de Madrid · ESUniversität Ulm · DEUniversity Hospital in Motol · CZUniversity of Foggia · ITUniversity of Glasgow · GBUniversity of Liège · BEUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo review the current literature and develop consensus conclusions and recommendations on nutrient intakes and nutritional practice in preterm infants with birthweight <1800 g.

methodsThe European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee of Nutrition (CoN) led a process that included CoN members and invited experts. Invited experts with specific expertise were chosen to represent as broad a geographical spread as possible. A list of topics was developed, and individual leads were assigned to topics along with other members, who reviewed the current literature. A single face-to-face meeting was held in February 2020. Provisional conclusions and recommendations were developed between 2020 and 2021, and these were voted on electronically by all members of the working group between 2021 and 2022. Where >90% consensus was not achieved, online discussion meetings were held, along with further voting until agreement was reached.

resultsIn general, there is a lack of strong evidence for most nutrients and topics. The summary paper is supported by additional supplementary digital content that provide a fuller explanation of the literature and relevant physiology: introduction and overview; human milk reference data; intakes of water, protein, energy, lipid, carbohydrate, electrolytes, minerals, trace elements, water soluble vitamins, and fat soluble vitamins; feeding mode including mineral enteral feeding, feed advancement, management of gastric residuals, gastric tube placement and bolus or continuous feeding; growth; breastmilk buccal colostrum, donor human milk, and risks of cytomegalovirus infection; hydrolyzed protein and osmolality; supplemental bionutrients; and use of breastmilk fortifier.

conclusionsWe provide updated ESPGHAN CoN consensus-based conclusions and recommendations on nutrient intakes and nutritional management for preterm infants.

Indexed as

GastroenterologyInfant, PrematureChildEnteral NutritionHumansInfantInfant, NewbornMilk, HumanVitaminsWaterVitaminsWater

Identifiers

PMID36705703
OpenAlexW4318256866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.