Evidence map›Paper›PMID 36705701›Full record

Observational studyJournal of pediatric gastroenterology and nutrition2023

Fecal Elastase in Preterm Infants to Predict Growth Outcomes.

Lindsay F Holzapfel, Amy B Hair, Geoffrey A Preidis, Tripti Halder, Heeju Yang, Jana P Unger, Steven Freedman, Camilia R Martin

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pediatric gastroenterology and nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Lindsay F HolzapfelFrom the Department of Pediatrics, Division of Neonatology, University of Texas at Houston Health Science Center, Houston, TX.
Amy B Hairthe Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Geoffrey A Preidisthe Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Tripti Halderthe Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
Heeju Yangthe Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Jana P Ungerthe Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Steven Freedmanthe Department of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Camilia R Martinthe Division of Neonatology, Weill Cornell Medicine, New York, NY.
Texas Children's Hospital · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USCornell University · USThe University of Texas Health Science Center at Houston · US

Funding

Institutional Career Development CoreKL2TR003168 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, CHARLES C · 2019 to 2023
$4.9M
Impact of fatty acid imbalance in intestinal health and disease in prematurityR01DK104346 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARTIN, CAMILIA R · 2014 to 2017
$2.8M
Nuclear receptor mediated bile acid alterations and coagulopathy in protein-energy undernutritionK08DK113114 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PREIDIS, GEOFFREY A · 2017 to 2021
$815k
NCATS NIH HHS KL2 TR003168NIDDK NIH HHS K08 DK113114NIDDK NIH HHS R01 DK104346
6 · The paper itself

Abstract

objectivesPreterm infants are born functionally pancreatic insufficient with decreased pancreatic production of lipase and proteases. Developmental pancreatic insufficiency (PI) may contribute to reduced nutrient absorption and growth failure. We sought to determine longitudinal fecal elastase (ELA1) levels in a cohort of preterm infants and whether levels are associated with growth outcomes.

methodsProspective observational study of 30 infants 24-34 weeks gestational age and birth weight ≤1250 g fed the exclusive human milk diet, consisting of human milk with human milk-based fortifier. ELA1 was quantified by ELISA during the first 2 weeks of life [Early; 7.5 ± 1.8 days of life (DOL)] and after attainment of full, fortified feedings (Late; 63.6 ± 24.1 DOL).

resultsEarly ELA1 levels were 192.2 ± 96.4 µg/g, and Late ELA1 levels were 268.0 ± 80.3 µg/g, 39.4% higher (P = 0.01). Infants with early PI (ELA1 < 200 µg/g) were more likely male and of lower gestational age, weight, length, and head circumference at birth. These variables, but not PI status, independently predicted somatic growth.

conclusionsFecal ELA1 in preterm infants fed exclusive human milk diet increases with postnatal age. Although pancreatic function in preterm infants may serve as a biological contributor to early postnatal growth failure, additional studies using fecal ELA1 as a predictive biomarker for growth failure are needed in larger cohorts.

Indexed as

Food, FortifiedInfant, PrematureHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaMaleMilk, HumanPancreatic ElastaseWeight GainPancreatic Elastase

Identifiers

PMID36705701
PMCPMC9886337
OpenAlexW4318256875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.