Evidence map›Paper›PMID 36705412›Full record

ArticleImmunity, inflammation and disease2023

The correlation of Th22 and regulatory T cells with Helicobacter pylori infection in patients with chronic gastritis.

Biyu Yao, Xiaoyan Xu, Weijie Liu, Qin Zhang, Wei Wang, Zhiming Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. The immunoregulatory role of helper T cells inFrontiers in immunology · 2025
    Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Biyu YaoDepartment of Gastroenterology, People's Hospital of Yuhuan, Zhejiang, Taizhou, China.ORCID 0000-0002-7381-6137
Xiaoyan XuDepartment of Gastroenterology, People's Hospital of Yuhuan, Zhejiang, Taizhou, China.
Weijie LiuDepartment of Gastroenterology, People's Hospital of Yuhuan, Zhejiang, Taizhou, China.
Qin ZhangDepartment of Gastroenterology, People's Hospital of Yuhuan, Zhejiang, Taizhou, China.
Wei WangDepartment of Gastroenterology, People's Hospital of Yuhuan, Zhejiang, Taizhou, China.
Zhiming HuangDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou, China.
Yuxian People's Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHelicobacter pylori is planted in the human stomach and is the most common cause of chronic gastritis, which produced specific local and systemic humoral immunity, while the associations of these immune responses and H. pylori in the development of chronic gastritis remain unclear.

methodsThis study analyzed histology, the number of Th22 and regulatory T (Treg) cells, and the levels of inflammation- and gastritis-related indicators between 22 H. pylori-infected and 24 non-H. pylori-infected chronic gastritis patients by hematoxylin-eosin staining, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR, and flow cytometry analysis.

resultsThis study found that the pathological damage degree of gastric mucosa in H. pylori infection patients was more serious. In the H. pylori-infected patient serum, the gastrin, G-17, interleukins (IL)-22, transforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α, IL-4, and IL-17A levels were notably raised, while the interferon (IFN)-γ level was inhibited, and in gastric mucosa, and except IFN-γ, the IL-22, forkhead box P3 (Foxp3), TNF-α, IL-4, and IL-17A mRNA levels were raised too. The receiver operating characteristic curve analysis indicates serum IL-22, TGF-β, TNF-α, IL-4, and IL-17A are suitable for differential diagnosis of H. pylori infection. In addition, in the peripheral blood, the percentages of the IL-22

conclusionsTreg and Th22 cells were positively associated with the degree of H. pylori infection and the severity of gastritis. In summary, this study provides an experimental basis for the study of the eradication of H. pylori and the biological mechanism of chronic gastritis.

Indexed as

GastritisHelicobacter InfectionsHelicobacter pyloriForkhead Transcription FactorsHumansInterferon-gammaInterleukin-17Interleukin-4RNA, MessengerT-Lymphocytes, RegulatoryTransforming Growth Factor betaTumor Necrosis Factor-alphaForkhead Transcription FactorsInterferon-gammaInterleukin-17Interleukin-4RNA, MessengerTransforming Growth Factor betaTumor Necrosis Factor-alphaflow cytometry analysisFoxp3IL-22Pearson's correlation analysisregulatory T cellsTh22 cells

Identifiers

PMID36705412
PMCPMC9846114
OpenAlexW4318263109

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.