SynthesisRenal failure2023
Efficacy of pre-emptive kidney transplantation for adults with end-stage kidney disease: a systematic review and meta-analysis.
Synthesis in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Referral for kidney transplantation: a consensus statement from the Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Association Between the Implementation of Shared Decision-Making and Clinical Characteristics of Living-Donor Kidney Transplantation.Healthcare (Basel, Switzerland) · 2026Article
- Kidney health for all: caring for people, protecting the planet.Kidney medicine · 2026Article
- Perioperative biomarkers and graft function in living donor kidney transplantation: focus on postoperative prognostic nutritional index.BMC nephrology · 2026Article
- Kidney health for all: Caring for people, protecting the planet.Journal of family medicine and primary care · 2026Article
- Kidney health for all: caring for people, protecting the planet.Kidney international reports · 2026Article
- Evaluating outcomes of preemptive kidney transplant in patients over 65 using high-KDPI kidneys compared to non-preemptive recipients.International urology and nephrology · 2026Article
- Impact of donor's acute kidney injury on graft outcomes of deceased donor kidney transplantation.Scientific reports · 2026Article
- Kidney Health for all: Caring for People, Protecting the Planet.Canadian journal of kidney health and disease · 2026Article
- Evaluating the efficacy of basiliximab versus no induction in low-immunological-risk kidney transplant recipients: a propensity score matched analysis.Renal failure · 2025Article
- Barriers Limiting Equity in Access to Pretransplant Evaluation Among Predialysis Patients: A Cohort Study.Transplantation direct · 2025Article
- Pretransplant Serum Creatinine in Peritoneal Dialysis Patients Predicts Graft Outcomes.Kidney medicine · 2025Article
- Uraemic burden index: a novel predictor of pre-emptive kidney transplant outcome.Clinical kidney journal · 2025Article
- Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors.Kidney medicine · 2025Review
- Trends in Timing of Preemptive Kidney Transplantation and Association with Allograft and Survival Outcomes in Children.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Pancreas transplant outcomes in patients with human immunodeficiency virus infection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Global transplantation: Lessons from organ transplantation organizations worldwide.World journal of transplantation · 2025Review
- Push toward pre-emptive kidney transplantation - for sure?Clinical kidney journal · 2024Review
- Time trends in preemptive kidney transplantation in Europe: an ERA registry study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Impact of Dialysis Time on Long-term Outcomes in HLA-identical Living Donor Kidney Transplant Recipients.Transplantation direct · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-emptive kidney transplantation (PEKT), i.e., transplantation performed before initiation of maintenance dialysis, is considered an ideal renal replacement therapy because there is no exposure to long-term dialysis therapy. Therefore, we summarized advantages/disadvantages of PEKT to assist in deciding whether kidney transplantation should be performed pre-emptively.
methodsThis study was registered with PROSPERO, CRD42021269163. Observational studies comparing clinical outcomes between PEKT and non-PEKT were included; those involving only pediatric recipients or simultaneous multi-organ transplantations were excluded. The PubMed/MEDLINE, Cochrane Library, and Ichushi-Web databases were searched on 1 August 2021. Studies were pooled using the generic inverse-variance method with random effects model, and risk of bias was assessed using ROBINS-I.
resultsSeventy-six studies were included in the systematic review (sample size, 23-121,853; enrollment year, 1968-2019). PEKT patients had lower all-cause mortality (adjusted HR: 0.78 [95% CI 0.66-0.92]), and lower death-censored graft failure (0.81 [0.67-0.98]). Unadjusted RRs for the following outcomes were comparable between the two patient groups: cardiovascular disease, 0.90 (0.58-1.40); biopsy-proven acute rejection, 0.75 (0.55-1.03); cytomegalovirus infection, 1.04 (0.85-1.29); and urinary tract infection, 0.89 (0.61-1.29). Mean differences in post-transplant QOL score were comparable in both groups. The certainty of evidence for mortality and graft failure was moderate and that for other outcomes was very low following the GRADE classification.
conclusionsThe present meta-analysis shows the potential benefits of PEKT, especially regarding patient and graft survival, and therefore PEKT is recommended for adults with end-stage kidney disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.