Evidence map›Paper›PMID 36704984›Full record

ArticleInternational journal of geriatric psychiatry2023

Impact of the Covid-19 pandemic on neuropsychiatric symptoms and antipsychotic prescribing for people with dementia in nursing home settings.

Joanne McDermid, Clive Ballard, Zunera Khan, Dag Aarsland, Chris Fox, Jane Fossey, Linda Clare, Esme Moniz-Cook, Maria Soto-Martin, Adrienne Sweetnam and 3 more

Abstract read
In one paragraph

Article in International journal of geriatric psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joanne McDermidUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Clive BallardUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Zunera KhanInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Dag AarslandInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Chris FoxUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Jane FosseyUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Linda ClareUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID https://orcid.org/0000-0003-3989-5318
Esme Moniz-CookFaculty of Health Sciences, University of Hull, Hull, UK.
Maria Soto-MartinCentre Hospitalier Universitaire de Toulouse, Toulouse, France.
Adrienne SweetnamUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Kathryn MillsUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Jeffrey CummingsChambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas (UNLV), Las Vegas, Nevada, USA.ORCID https://orcid.org/0000-0001-8944-4158
Anne CorbettUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID https://orcid.org/0000-0003-2015-0316

Funding

Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI JESSICA KIRKLAND CALDWELL · 2015 to 2026
$22.8M
Department of HealthMedical Research Council MR/V027794/1NIGMS NIH HHS P20 GM109025
6 · The paper itself

Abstract

objectivesThis study aimed to determine the impact of the Covid-19 pandemic on neuropsychiatric symptoms and antipsychotic use in people with dementia living in nursing homes.

methodsThis was a comparative analysis of baseline data from two large nursing home studies, one conducted during (COVID-iWHELD study) and one prior (WHELD study) to the pandemic. It involves data from 69 and 149 nursing homes, and 1006 and 666 participants respectively. Participants were people with established dementia (score >1 on Clinical Dementia Rating Scale). Resident data included demographics, antipsychotic prescriptions and neuropsychiatric symptoms using the Neuropsychiatric Inventory Nursing Home version. Nursing home data collected were nursing home size and staffing information.

resultsOverall prevalence of neuropsychiatric symptoms was unchanged from pre-pandemic prevalence. Mean antipsychotic use across the sample was 32.0%, increased from 18% pre-pandemic (Fisher's exact test p < 0.0001). At a nursing home level, the medians for the low, medium and high tertiles for antipsychotic use were 7%, 20% and 59% respectively, showing a disproportionate rise in tertile three. Residents in these homes also showed a small but significant increase in agitation.

conclusionThere has been a significant increase in antipsychotic prescribing in nursing homes since the COVID-19 pandemic, with a disproportionate rise in one third of homes, where median prescription rates for antipsychotics were almost 60%. Strategies are urgently needed to identify these nursing homes and introduce pro-active support to bring antipsychotic prescription rates back to pre-pandemic levels.

Indexed as

Antipsychotic AgentsCOVID-19DementiaHumansNursing HomesPandemicsAntipsychotic AgentsantipsychoticsCoviddementianeuropsychiatricnursing home

Identifiers

PMID36704984
PMCPMC10286750

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.