Evidence map›Paper›PMID 36704746›Full record

ArticleFrontiers in psychiatry2022

Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan.

Ming-Chen Tsai, Chia-Lin Tsai, Chih-Sung Liang, Yu-Kai Lin, Guan-Yu Lin, Chia-Kuang Tsai, Po-Kuan Yeh, Yi Liu, Kuo-Sheng Hung, Fu-Chi Yang

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In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ming-Chen TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Chia-Lin TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Chih-Sung LiangDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Yu-Kai LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Guan-Yu LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Chia-Kuang TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Po-Kuan YehDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Yi LiuDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Kuo-Sheng HungCenter for Precision Medicine and Genomics, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Fu-Chi YangDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Tri-Service General Hospital · TWNational Defense Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The genetic association between depression and migraine has not been well investigated in Asian populations. Furthermore, the genetic basis of depression and comorbid migraine subtypes remains nebulous. Hence, in the current study we investigate the susceptibility loci associated with depression and migraine comorbidity in the Han Chinese population in Taiwan. Methods: We perform a genome-wide association study involving 966 migraine patients, with or without comorbid depression. Genotyping is performed using participant genomic DNA. Association analyses are performed for the entire migraine cohort (subgroups: episodic migraine, chronic migraine, and migraine with or without aura). Results: Results show that the single nucleotide polymorphism variants of the Discussion: The findings of this study identify several genetic loci suggestively associated with depression among migraine patients in the Han Chinese population. Moreover, a potential genetic basis has been characterized for depression and migraine comorbidity, thus providing genetic candidates for further investigation.

Indexed as

depressiongenetic variantHan Chinesemigrainesingle nucleotide polymorphism (SNP)susceptibility loci

Identifiers

PMID36704746
PMCPMC9871634
OpenAlexW4315471703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.