Evidence map›Paper›PMID 36704480›Full record

ArticleFrontiers in cardiovascular medicine2022

SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke.

Manuela De Michele, Svetlana Lorenzano, Paola Piscopo, Roberto Rivabene, Alessio Crestini, Antonio Chistolini, Lucia Stefanini, Fabio M Pulcinelli, Irene Berto, Roberta Campagna and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Pathogenic mechanisms of cardiovascular damage in COVID-19.Molecular medicine (Cambridge, Mass.) · 2024
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Manuela De MicheleEmergency Department, Stroke Unit, Sapienza University of Rome, Rome, Italy.
Svetlana LorenzanoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Paola PiscopoDepartment of Neuroscience, Istituto Superiore di Sanità, Rome, Italy.
Roberto RivabeneDepartment of Neuroscience, Istituto Superiore di Sanità, Rome, Italy.
Alessio CrestiniDepartment of Neuroscience, Istituto Superiore di Sanità, Rome, Italy.
Antonio ChistoliniHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Lucia StefaniniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Fabio M PulcinelliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Irene BertoEmergency Department, Stroke Unit, Sapienza University of Rome, Rome, Italy.
Roberta CampagnaDepartment of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy.
Paolo AmisanoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Marta IacobucciNeuroradiology Unit, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Carlo CirelliNeuroradiology Unit, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Anne FalcouEmergency Department, Stroke Unit, Sapienza University of Rome, Rome, Italy.
Ettore NicoliniEmergency Department, Stroke Unit, Sapienza University of Rome, Rome, Italy.
Oscar G SchiavoEmergency Department, Stroke Unit, Sapienza University of Rome, Rome, Italy.
Danilo ToniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Acute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims of this study were to compare clinical/radiological characteristics, endothelial and coagulation dysfunction between acute ischemic stroke (AIS) patients with and without COVID-19 and to investigate if and how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation. Methods: We enrolled AIS patients with COVID-19 within 12 h from onset and compared them with an age- and sex-matched cohort of AIS controls without COVID-19. Neuroimaging studies were performed within 24 h. Blood samples were collected in a subset of 10 patients. Results: Of 39 AIS patients, 22 had COVID-19 and 17 did not. Admission levels of Factor VIII and von Willebrand factor antigen were significantly higher in COVID-19 patients and positively correlated with the infarct volume. In multivariate linear regression analyses, COVID-19 was an independent predictor of infarct volume (B 20.318, Beta 0.576, 95%CI 6.077-34.559; Conclusions: SARS-CoV-2 infection seems to play a major role in endothelium activation and infarct volume extension during AIS.

Indexed as

coagulationCOVID-19endothelium activationplatelet activationSARS-CoV-2strokethrombosis

Identifiers

PMID36704480
PMCPMC9871539
OpenAlexW4315433972

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.