ArticleFrontiers in cardiovascular medicine2022
Hyperuricemia predicts increased cardiovascular events in patients with chronic coronary syndrome after percutaneous coronary intervention: A nationwide cohort study from Japan.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Peak aortic jet velocity as a predictor of short- and long-term outcomes following percutaneous coronary intervention.International journal of cardiology. Heart & vasculature · 2026Article
- Predicting Left Ventricular Ejection Fraction Recovery After Percutaneous Coronary Intervention in Patients With Chronic Coronary Syndrome by Using Interpretable Machine Learning Models: Retrospective Study.JMIR medical informatics · 2025Article
- Comparison of the Efficacy of Empagliflozin, Dapagliflozin, and Allopurinol Based on Serum Uric Acid Levels and Kidney Function in Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study.Medical sciences (Basel, Switzerland) · 2025Article
- Gout, Uric Acid, and Coronary Artery Disease.Journal of atherosclerosis and thrombosis · 2025Review
- Prognostic Value of the NAPLES Score and Serum Uric Acid in Chronic Coronary Syndrome: Evidence from Time-Dependent ROC and Time-Varying Hazard Ratio Analyses.Journal of clinical medicine · 2025Article
- Progress in Prognostic Metabolic Biomarkers for Coronary Artery Disease Patients Post-Percutaneous Coronary Intervention.Reviews in cardiovascular medicine · 2025Review
- Analysis of ABCG2 gene rs2231142 single nucleotide polymorphism and risk factors in hyperuricemia.Scientific reports · 2025Article
- Changes in systolic blood pressure during hospitalisation and bleeding events after percutaneous coronary intervention.Open heart · 2024Article
- Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.Journal of clinical medicine · 2024Review
- Relationship between the number of drugs used during percutaneous coronary intervention and adverse events in patients with chronic coronary syndrome: Analysis of CLIDAS database.International journal of cardiology. Heart & vasculature · 2024Article
- Progress of uric acid in cardiovascular disease.Cardiovascular endocrinology & metabolism · 2024Review
- Association of serum uric acid with functional disability in older subjects: a population-based study.Aging clinical and experimental research · 2024Article
- Expert consensus for the diagnosis and treatment of patients with hyperuricemia and high cardiovascular risk: 2023 update.Cardiology journal · 2024Article
- BNP level predicts bleeding event in patients with heart failure after percutaneous coronary intervention.Open heart · 2023Article
- Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases.Biomolecules · 2023Review
- Update in uric acid, hypertension, and cardiovascular diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Hyperuricaemia: prevalence and association with mortality in an elderly Finnish population.BMJ open · 2023Article
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Authors and funding
22 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The causal relationship between hyperuricemia and cardiovascular diseases is still unknown. We hypothesized that hyperuricemic patients after percutaneous coronary intervention (PCI) had a higher risk of major adverse cardiovascular events (MACE). Methods: This was a large-scale multicenter cohort study. We enrolled patients with chronic coronary syndrome (CCS) after PCI between April 2013 and March 2019 using the database from the Clinical Deep Data Accumulation System (CLIDAS), and compared the incidence of MACE, defined as a composite of cardiovascular death, myocardial infarction, and hospitalization for heart failure, between hyperuricemia and non-hyperuricemia groups. Results: In total, 9,936 patients underwent PCI during the study period. Of these, 5,138 patients with CCS after PCI were divided into two group (1,724 and 3,414 in the hyperuricemia and non-hyperuricemia groups, respectively). The hyperuricemia group had a higher prevalence of hypertension, atrial fibrillation, history of previous hospitalization for heart failure, and baseline creatinine, and a lower prevalence of diabetes than the non-hyperuricemia group, but the proportion of men and age were similar between the two groups. The incidence of MACE in the hyperuricemia group was significantly higher than that in the non-hyperuricemia group (13.1 vs. 6.4%, log-rank Conclusion: CLIDAS revealed that hyperuricemia was associated with increased MACE in patients with CCS after PCI. Further clinical trials are needed whether treating hyperuricemia could reduce cardiovascular events or not.
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