ArticleHealth science reports2023
The etiological effect and genetic risk of +252 A/G variant of TNF-β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study.
Article in Health science reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Establishment and validation of a risk prediction model for urinary tract infection in elderly patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- The etiological effect and genetic risk of +252 A/G variant of TNF-β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study.Health science reports · 2023Article
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2 authors at 1 institution in 1 country.
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Abstract
Background and aim: Urinary tract infection (UTI) is the most common infection in type 2 diabetes patients. TNF-β is a cytokine with multiple functions in immunomodulatory and inflammatory mechanisms. The variation at position +252 A/G of TNF-β impacts both gene expression and plasma concentration of TNF-β proteins. The findings may shed light on the genetic factors that predispose diabetic patients in Iraq to UTIs. Methods: A total of 200 individuals were divided into 100 patients with type 2 diabetes, categorized according to UTI, and 100 control subjects. Genetic analysis of +252 A/G of the TNF-β gene was carried out using the TaqMan probe allele discrimination method. The level of TNF-β was estimated by the ELISA technique. Results: In the recessive model (GG vs. AA/AG) of TNF-β + 252 A/G in T2D/UTI patients compared to controls, a significant association Conclusion: In T2D patients, the G allele may be linked to a higher probability of UTI, as well as an increased level of TNF-β in a genotype-dependent manner.
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