Evidence map›Paper›PMID 36704297›Full record

ReviewFrontiers in bioengineering and biotechnology2022

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations.

Wei Tan, Parnaz Boodagh, Prakash Parthiban Selvakumar, Sean Keyser

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Biofabrication of engineered blood vessels for biomedical applications.Science and technology of advanced materials · 2024
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Wei TanDepartment of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United States.
Parnaz BoodaghMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
Prakash Parthiban SelvakumarDepartment of Mechanical Engineering, North Dakota State University, Fargo, ND, United States.
Sean KeyserDepartment of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United States.
University of Colorado Boulder · USMcGowan Institute for Regenerative Medicine · USNorth Dakota State University · US

Funding

Synthetic Mesenchymal Stem Cell Niches for Vascular TherapyR01HL119371 · NHLBI · UNIVERSITY OF COLORADO · PI TAN, WEI · 2013 to 2023
$5.0M
NHLBI NIH HHS R01 HL119371
6 · The paper itself

Abstract

Vascular grafts are widely used for vascular surgeries, to bypass a diseased artery or function as a vascular access for hemodialysis. Bioengineered or tissue-engineered vascular grafts have long been envisioned to take the place of bioinert synthetic grafts and even vein grafts under certain clinical circumstances. However, host responses to a graft device induce adverse remodeling, to varied degrees depending on the graft property and host's developmental and health conditions. This in turn leads to invention or failure. Herein, we have mapped out the relationship between the design constraints and outcomes for vascular grafts, by analyzing impairment factors involved in the adverse graft remodeling. Strategies to tackle these impairment factors and counteract adverse healing are then summarized by outlining the research landscape of graft innovations in three dimensions-cell technology, scaffold technology and graft translation. Such a comprehensive view of cell and scaffold technological innovations in the translational context may benefit the future advancements in vascular grafts. From this perspective, we conclude the review with recommendations for future design endeavors.

Indexed as

adverse remodelingcell technologyimpairment factorscaffold technologyvascular grafts

Identifiers

PMID36704297
PMCPMC9871289
OpenAlexW4314937971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.