ArticleFrontiers in plant science2022
Transcriptomics integrated with widely targeted metabolomics reveals the cold resistance mechanism in
Article in Frontiers in plant science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
- Integrated analysis of structure, physiology, transcriptome and metabolome reveals key metabolic pathway responses of cold-tolerant pear cultivar germplasms under low-temperature stress.BMC plant biology · 2026Article
- Integrated metabolomic, cytotoxic, and computational investigation of Caralluma tuberculata extract in breast cancer cells.Scientific reports · 2026Article
- Molecular mechanisms associated with rootstock-scion interactions in rubber trees.The plant genome · 2026Article
- RrLHY regulates arginine biosynthesis by activating RrNAGS1 in Rosa roxburghii fruit.Plant cell reports · 2026Article
- Winter tapping of cold-tolerant rubber clone Yunyan 77-4: a viable strategy to reschedule the production season and capture potential market premiums in China.Frontiers in plant science · 2026Article
- Structural and functional perspectives on DEAD-box RNA helicases in the rubber tree cold stress response.Frontiers in plant science · 2026Review
- Overexpression ofPlants (Basel, Switzerland) · 2025Article
- Transcriptomic Analysis of Differential Gene Expression inPlants (Basel, Switzerland) · 2025Article
- Unveiling the effects of metabolites on the material properties of natural rubber by the integration of metabolomics and material characteristics.Scientific reports · 2025Article
- Transcriptome and metabolome reveal the primary and secondary metabolism changes in Larix gmelinii seedlings under abiotic stress.BMC plant biology · 2024Article
- Integrated Transcriptomics and Metabolomics Analysis Reveals the Effects of Cutting on the Synthesis of Flavonoids and Saponins in Chinese Herbal MedicineMetabolites · 2024Article
- Key anti-freeze genes and pathways of Lanzhou lily (Lilium davidii, var. unicolor) during the seedling stage.PloS one · 2024Article
- Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects.Frontiers in chemistry · 2024Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rubber tree is the primary source of natural rubber and is mainly cultivated in Southeast Asian countries. Low temperature is the major abiotic stress affecting the yield of the rubber tree. Therefore, uncovering the cold resistance mechanism in the rubber tree is necessary. The present study used RNA-sequencing technology and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze the transcriptomic and metabolomic changes in two rubber tree clones with different cold resistance capacities (temperature-sensitive Reyan 8-79 and cold-resistant Yunyan 77-4) at 0 h, 2 h, 6 h, and 20 h of exposure to 4°C. Independent analysis of the transcriptome and metabolitome showed that under prolonged low-temperature treatment, Yunyan 77-4 expressed more genes involved in regulating enzyme activity, changing cell permeability, and synthesizing significant metabolites, such as flavonoids and amino acids, than Reyan 8-79. The KEGG annotation and enrichment analysis identified arginine metabolism and biosynthesis of flavonoids as the major pathway associated with cold resistance. Integrated transcriptome and metabolome analysis showed that the increase in the expression of genes modulated flavonoid biosynthesis, arginine biosynthesis, and anthocyanins biosynthesis, resulting in higher levels of metabolites, such as naringenin chalcone, apigenin, dihydroquercetin, cyanidin 3-glucoside, L-arginosuccinate, N-acetyl-ornithine, ornithine, and N-acetyl-glutamate, in Yunyan 77-4 than in Reyan 8-79 after prolonged low-temperature treatment. Phylogenetic analysis identified the genes, such as CHS (
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