Evidence map›Paper›PMID 36704122›Full record

ArticlePNAS nexus2022

Stochastic activation of a family of TetR type transcriptional regulators controls phenotypic heterogeneity in

María Pérez-Varela, Aimee R P Tierney, Emma Dawson, Anna R Hutcheson, Kyle A Tipton, Sarah E Anderson, Marina E Haldopoulos, Shaina Song, Brooke R Tomlinson, Lindsey N Shaw and 3 more

Open access · goldAbstract read
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. Review
  5. Carbapenem-ResistantMicroorganisms · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

María Pérez-VarelaDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
Aimee R P TierneyDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
Emma DawsonDepartment of Physics, Emory University, Atlanta, GA 30322, USA.
Anna R HutchesonResearch Service, Atlanta VA Medical Center, Decatur, GA 30033, USA.
Kyle A TiptonDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
Sarah E AndersonDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0003-2064-8165
Marina E HaldopoulosEmory Antibiotic Resistance Center, Emory University, Atlanta, GA 30322, USA.
Shaina SongResearch Service, Atlanta VA Medical Center, Decatur, GA 30033, USA.
Brooke R TomlinsonDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA.
Lindsey N ShawDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA.ORCID https://orcid.org/0000-0002-0629-8990
David S WeissResearch Service, Atlanta VA Medical Center, Decatur, GA 30033, USA.
Minsu KimDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0003-1594-4971
Philip N RatherDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
Emory University · USAtlanta VA Medical Center · USUniversity of South Florida · US

Funding

The Role and Regulation of Extracellular Proteases in Staphylococcus aureusR01AI124458 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2017 to 2020
$1.7M
Dissecting the Influence of a C-Terminal Processing Protease on S. aureus PathogenesisR01AI157506 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SHAW, LINDSEY NEIL · 2021 to 2024
$1.5M
Regulation of a virulence switch in Acinetobacter baumanniiR21AI142489 · NIAID · EMORY UNIVERSITY · PI RATHER, PHILIP N. · 2019 to 2020
$349k
Manipulating a Virulence Switch to Combat Acinetobacter baumannii InfectionsI01BX001725 · VA · VETERANS HEALTH ADMINISTRATION · PI RATHER, PHILIP N. · 2013 to 2024
–
BLRD VA I01 BX001725NIAID NIH HHS R01 AI124458NIAID NIH HHS R01 AI157506NIAID NIH HHS R21 AI142489
6 · The paper itself

Abstract

Phenotypic heterogeneity is an important mechanism for regulating bacterial virulence, where a single regulatory switch is typically activated to generate virulent and avirulent subpopulations. The opportunistic pathogen

Indexed as

Acinetobacterphenotypic heterogeneityTetR regulator

Identifiers

PMID36704122
PMCPMC9802203
OpenAlexW4308833302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.